NewsBIOCHEMICAL PHARMACOLOGYWednesday, December 24, 2025 · December 24, 2025
Agomelatine alleviates hypoxia-induced pulmonary arterial hypertension by activating mitophagy via the SIRT1/FoxO1/ULK1 signaling pathway.
WHY IT MATTERS
Recent peer-reviewed research on Pulmonary arterial hypertension that may be relevant for patients and caregivers.
Human melatonin receptor type 1/2 (MTR1/MTR2) are widely distributed throughout the body and play essential roles in regulating cardiovascular physiology. However, the therapeutic potential of agomelatine (AGM), a melatonin analog and nonselective MTR1/MTR2 agonist, in pulmonary arterial hypertensio...
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