NewsCELL PROLIFERATIONFriday, April 3, 2026 · April 3, 2026
PIK-III-Mediated Elevation of Thiamine Re-Sensitises Renal Cell Carcinoma to Cuproptosis via Activating PDHA1.
WHY IT MATTERS
Recent peer-reviewed research on Renal cell carcinoma that may be relevant for patients and caregivers.
Cuproptosis, a copper-dependent cell death mechanism driven by tricarboxylic acid (TCA) cycle collapse, shows limited efficacy in hypoxic or glycolytic renal cell carcinoma (RCC). Here, through systematic screening of 688 glycolysis inhibitors combined with elesclomol (ES), we identified PIK-III as ...
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