NewsINTERNATIONAL JOURNAL OF HEMATOLOGYSaturday, March 7, 2026 · March 7, 2026
BRD9 depletion-mediated ALOX5 upregulation via chromatin dysregulation induces ferroptosis in SF3B1-mutant hematopoiesis.
WHY IT MATTERS
Recent peer-reviewed research on Myelodysplastic syndrome that may be relevant for patients and caregivers.
SF3B1 mutations are among the most common splicing factor mutations in myeloid malignancies, yet the mechanisms linking aberrant splicing to metabolic phenotypes remain incompletely understood. We previously demonstrated that SF3B1 mutations cause nonsense-mediated decay of BRD9, a core component of...
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