NewsNATURE GENETICSWednesday, April 15, 2026 · April 15, 2026
Large-scale exome analyses reveal new rare variant contributions in amyotrophic lateral sclerosis.
WHY IT MATTERS
Recent peer-reviewed research on Amyotrophic Lateral Sclerosis (ALS) that may be relevant for patients and caregivers.
Amyotrophic lateral sclerosis (ALS) is a heritable disorder where rare variants with low-to-moderate penetrance are thought to dominate genetic risk. To identify such rare variants, we harmonized and analyzed exome data from 22 cohorts, totaling 17,919 individuals with ALS and 200,703 controls acros...
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