NewsHAEMATOLOGICAWednesday, April 1, 2026 · April 1, 2026
TGFβ-activated kinase-1 knockdown in hematopoietic stem-progenitor cells causes PANoptosis and myelodysplastic syndrome-like disease in mice.
WHY IT MATTERS
Recent peer-reviewed research on Myelodysplastic syndrome that may be relevant for patients and caregivers.
Mutant SF3B1 (SF3B1mut) in hematopoietic stem/progenitor cells (HSPC) primarily affects erythropoiesis, resulting in myelodysplastic syndromes (MDS) with refractory macrocytic anemia and ring sideroblasts. SF3B1mut results in aberrant splicing of a large number of transcripts in HSPC due to the alte...
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