NewsLEUKEMIAWednesday, April 22, 2026 · 4 days ago
PRMT5 inhibition sensitizes B-cell lymphoma cells to ferroptosis.
WHY IT MATTERS
Recent peer-reviewed research on Mantle cell lymphoma that may be relevant for patients and caregivers.
Protein arginine methyltransferase 5 (PRMT5) is overexpressed in B-cell lymphomas, including diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL). While PRMT5 is known to regulate multiple oncogenic pathways, including PI3K-AKT signaling, its role in lipid metabolism and ferroptosis,...
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