NewsKIDNEY INTERNATIONALSaturday, April 18, 2026 · April 18, 2026
Evidence from multicenter clinical studies and humanized mouse models indicates that glomerular mesangial IgA2 deposition contributes to the pathogenesis of IgA nephropathy.
WHY IT MATTERS
Recent peer-reviewed research on IgA Nephropathy that may be relevant for patients and caregivers.
While IgA1 is well established as pathogenic in IgA nephropathy (IgAN), IgA2's role remains controversial. The most notable difference between IgA1 and IgA2 lies in the hinge region: IgA2 lacks a 13-amino acid segment unique in IgA1, which contains nine serine and threonine residues that can be O-gl...
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