NewsBIORXIV : THE PREPRINT SERVER FOR BIOLOGYWednesday, March 11, 2026 · March 11, 2026
cGAS inhibition delays TDP-43-driven ALS Pathogenesis.
WHY IT MATTERS
Recent peer-reviewed research on Amyotrophic Lateral Sclerosis (ALS) that may be relevant for patients and caregivers.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder marked by motor neuron loss and cytoplasmic mislocalization of TAR DNA-binding protein 43 (TDP-43), a key regulator of RNA splicing. However, the upstream modulators of this process remain poorly defined. Here we identify cycl...
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