NewsINTERNATIONAL IMMUNOPHARMACOLOGYTuesday, January 6, 2026 · January 6, 2026
Lactate represses MHC-I antigen presentation via H4K5 lactylation-PRC2 in small cell lung cancer subtype A.
WHY IT MATTERS
Recent peer-reviewed research on Small cell lung cancer that may be relevant for patients and caregivers.
Small cell lung cancer (SCLC) responds poorly to immunotherapy. This study investigates how glycolytic reprogramming drives immune evasion in SCLC by epigenetically suppressing MHC-I mediated antigen presentation. Bioinformatic and murine model studies confirmed SCLC with high ASCL1 expression (SCLC...
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