Unicentric Castleman disease

Last reviewed March 21, 2026

🖨 Print for my doctor Advocacy Hub →

ORPHA:93685D47.7

Who is this for?

Show terms as

1FDA treatments 11Specialists 8Treatment centers 1Financial resources

Where are you in your journey?

ℹ

UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.

Report missing data

Overview

Also known as:

Localized Castleman disease

Orphanet ↗NORD ↗

FDA & Trial Timeline

1 event

Apr 2014

SYLVANT: FDA approved

Treatment of patients with multicentric Castleman's disease (MCD) who are human immunodeficiency virus (HIV) negative and human herpesvirus-8 (HHV-8) negative.

FDAcompleted

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

1 available

SYLVANT

siltuximab· Recordati Rare Diseases Inc.Orphan Drug

Treatment of patients with multicentric Castleman's disease (MCD) who are human immunodeficiency virus (HIV) negative and human herpesvirus-8 (HHV-8) negative.

View Details →FDA Label ↗Copay Card ↗Patient Assistance ↗

Clinical Trials

View all trials with filters →

No actively recruiting trials found for Unicentric Castleman disease at this time.

New trials open frequently. Follow this disease to get notified.

Search ClinicalTrials.gov ↗Join the Unicentric Castleman disease community →

Specialists

11 foundView all specialists →

RM

Robert Yarchoan, M.D.

Bethesda, Maryland

Specialist

Rare Disease Specialist

Castleman disease Harlequin ichthyosis HIV-associated cancer+6 more

PI on 13 active trials

Active trials Directions Travel grants

RM

Ramya M Ramaswami, M.D.

Bethesda, Maryland

Specialist

Rare Disease Specialist

B-cell non-Hodgkin lymphoma Castleman disease HIV-associated cancer+6 more

PI on 10 active trials

Active trials Directions Travel grants

JM

Joshua Brandstadter, MD, PhD, MSc

PHILADELPHIA, PA

Specialist

Castleman disease Corneal dystrophy Macular corneal dystrophy

PI on 3 active trials

Active trials Directions Travel grants

PM

Pier Luigi Zinzani, MD

Specialist

Autoimmune lymphoproliferative syndrome Castleman disease Classic hairy cell leukemia+2 more

PI on 5 active trials

Active trials Directions Travel grants

MM

Matthew Painschab, MD

INDIANAPOLIS, IN

Specialist

Castleman disease Corneal dystrophy Macular corneal dystrophy

PI on 1 active trial

Active trials Directions Travel grants

VM

Vera Krymskaya, PhD, MBA

Specialist

Castleman disease Macular corneal dystrophy

PI on 1 active trial

Active trials Directions Travel grants

SP

Sarina A Piha-Paul

Houston, Texas

Specialist

Rare Disease Specialist

Castleman disease Erdheim-Chester disease Langerhans cell sarcoma+2 more

PI on 2 active trials2 Unicentric Castleman disease publications

Active trials Directions Travel grants

AP

Antonio T. Fojo, MD, PhD

BALTIMORE, MD

Specialist

Castleman disease Epithelioid hemangioma

PI on 1 active trial

Active trials Directions Travel grants

SM

Sascha Tuchman, MD

DURHAM, NC

Specialist

Castleman disease Heavy chain deposition disease Heavy chain disease+3 more

PI on 1 active trial

Active trials Directions Travel grants

JB

Jeff Bethony

Specialist

Castleman disease

PI on 1 active trial1 Unicentric Castleman disease publication

Active trials Directions Travel grants

JM

J. Michael Berry, MD

Specialist

Castleman disease

PI on 1 active trial

Active trials Directions Travel grants

Treatment Centers

8 centers

Baylor College of Medicine Rare Disease Center ↗

Baylor College of Medicine

📍 Houston, TX

Stanford Medicine Rare Disease Center ↗

Stanford Medicine

📍 Stanford, CA

NIH Clinical Center Undiagnosed Diseases Program ↗

National Institutes of Health

📍 Bethesda, MD

UCLA UDN Clinical Site ↗

UCLA Health

📍 Los Angeles, CA

Baylor College of Medicine UDN Clinical Site ↗

Baylor College of Medicine

📍 Houston, TX

Harvard/MGH UDN Clinical Site ↗

Massachusetts General Hospital

📍 Boston, MA

Mayo Clinic Center for Individualized Medicine ↗

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

UCLA Rare Disease Day Program ↗

UCLA Health

📍 Los Angeles, CA

Financial Resources

1 resources

SYLVANT(siltuximab)— Recordati Rare Diseases Inc.

Copay Card ↗Patient Assistance ↗

Travel Grants

No travel grants are currently matched to Unicentric Castleman disease.

Search all travel grants →NORD Financial Assistance ↗

Community

Open Unicentric Castleman diseaseForum →

No community posts yet. Be the first to share your experience with Unicentric Castleman disease.

Start the conversation →

Latest news about Unicentric Castleman disease

No recent news articles for Unicentric Castleman disease.

Follow this condition to be notified when news becomes available.

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Unicentric Castleman disease

Which specialists treat Unicentric Castleman disease?

11 specialists and care centers treating Unicentric Castleman disease are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.

What treatment and support options exist for Unicentric Castleman disease?

1 patient support program are currently tracked on UniteRare for Unicentric Castleman disease. See the treatments and support programs sections for copay assistance, eligibility, and contact details.