Sympathetic ophthalmia

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ORPHA:79098H44.1
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16Specialists8Treatment centers

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UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Sympathetic ophthalmia (also called sympathetic uveitis or bilateral granulomatous uveitis) is a rare but serious inflammatory eye disease. It happens when one eye is injured or has surgery, and then — sometimes weeks, months, or even years later — the other, uninjured eye also becomes inflamed. The immune system mistakenly attacks both eyes as if they were foreign tissue. The injured eye is called the 'exciting eye,' and the uninjured eye that later becomes affected is called the 'sympathizing eye.' The main symptoms include eye pain, redness, blurred vision, sensitivity to light, and floaters. In severe cases, it can lead to permanent vision loss or even blindness in both eyes if not treated quickly. The disease can affect people of any age, from children to older adults, and usually develops after a penetrating eye injury or eye surgery. Treatment focuses on calming the immune system using corticosteroids (like prednisone) and other immunosuppressive medicines. Early diagnosis and prompt treatment are very important to protect vision. In some cases, the injured eye may need to be removed to prevent the condition from starting or worsening, though this is a difficult decision made carefully with a specialist.

Also known as:

Key symptoms:

Eye pain in one or both eyesRedness of the eyeBlurred or decreased visionSensitivity to light (photophobia)Floaters (spots or strings drifting across vision)Tearing or watery eyesHeadache around the eyesDifficulty focusingSwelling inside the eyeLoss of peripheral (side) visionSeeing halos around lights

Clinical phenotype terms (26)— hover any for plain English
VitritisHP:0011531Corneal keratic precipitatesHP:0025341Anterior chamber cellsHP:0025560Scleral thickeningHP:0030823Retinal hemorrhageHP:0000573VitiligoHP:0001045PapilledemaHP:0001085PoliosisHP:0002290Fundus hypopigmentationHP:0007894Ocular hypertensionHP:0007906
Inheritance

Sporadic

Usually appears on its own, not inherited from a parent

Age of Onset

Variable

Can begin at different ages, from infancy through adulthood

Orphanet ↗NORD ↗

Treatments

No FDA-approved treatments are currently listed for Sympathetic ophthalmia.

View clinical trials →

No actively recruiting trials found for Sympathetic ophthalmia at this time.

New trials open frequently. Follow this disease to get notified.

Search ClinicalTrials.gov ↗Join the Sympathetic ophthalmia community →

Specialists

16 foundView all specialists →
CP
Carlos Pavesio
Specialist
2 Sympathetic ophthalmia publications
BH
Bonnie He
Specialist
2 Sympathetic ophthalmia publications
EI
Edsel Ing
Specialist
2 Sympathetic ophthalmia publications
MA
Manisha Agarwal
CLEVELAND, OH
Specialist
2 Sympathetic ophthalmia publications
TM
Thomas Ciulla, MD
CARMEL, IN
Specialist
PI on 8 active trials
AG
Anil Gangwe
Specialist
1 Sympathetic ophthalmia publication
SB
Shashwat Behera
Specialist
1 Sympathetic ophthalmia publication
SM
Samyak Mulkutkar
Specialist
1 Sympathetic ophthalmia publication
GB
Gulshan Barwar
Specialist
1 Sympathetic ophthalmia publication
DA
Deepshikha Agrawal
Specialist
1 Sympathetic ophthalmia publication
WG
Weidong Gu
Specialist
2 Sympathetic ophthalmia publications
SP
Swapnil Parchand
Specialist
1 Sympathetic ophthalmia publication
TP
Tim J Patterson
Specialist
2 Sympathetic ophthalmia publications
AA
Aniruddha Agarwal
OMAHA, NE
Specialist
1 Sympathetic ophthalmia publication
PB
Priyavat Bhatia
Specialist
1 Sympathetic ophthalmia publication
NA
Nikitha Ayyadurai
Specialist
1 Sympathetic ophthalmia publication

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Sympathetic ophthalmia.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Sympathetic ophthalmia

No recent news articles for Sympathetic ophthalmia.

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Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Questions for your doctor

Bring these to your next appointment

  • Q1.How quickly do I need to start treatment, and what are the risks if we wait?,What are the chances that my vision can be preserved with treatment?,What are the side effects of the medicines you are recommending, and how will we monitor for them?,How long will I need to take immunosuppressive medicines?,Should the injured eye be removed, and what are the pros and cons of that decision?,How often do I need follow-up appointments, and what warning signs should make me come in sooner?,Are there clinical trials or newer treatments I should know about?

Common questions about Sympathetic ophthalmia

What is Sympathetic ophthalmia?

Sympathetic ophthalmia (also called sympathetic uveitis or bilateral granulomatous uveitis) is a rare but serious inflammatory eye disease. It happens when one eye is injured or has surgery, and then — sometimes weeks, months, or even years later — the other, uninjured eye also becomes inflamed. The immune system mistakenly attacks both eyes as if they were foreign tissue. The injured eye is called the 'exciting eye,' and the uninjured eye that later becomes affected is called the 'sympathizing eye.' The main symptoms include eye pain, redness, blurred vision, sensitivity to light, and floate

How is Sympathetic ophthalmia inherited?

Sympathetic ophthalmia follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.

Which specialists treat Sympathetic ophthalmia?

16 specialists and care centers treating Sympathetic ophthalmia are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.