Overview
Sympathetic ophthalmia (also called sympathetic uveitis or bilateral granulomatous uveitis) is a rare but serious inflammatory eye disease. It happens when one eye is injured or has surgery, and then — sometimes weeks, months, or even years later — the other, uninjured eye also becomes inflamed. The immune system mistakenly attacks both eyes as if they were foreign tissue. The injured eye is called the 'exciting eye,' and the uninjured eye that later becomes affected is called the 'sympathizing eye.' The main symptoms include eye pain, redness, blurred vision, sensitivity to light, and floaters. In severe cases, it can lead to permanent vision loss or even blindness in both eyes if not treated quickly. The disease can affect people of any age, from children to older adults, and usually develops after a penetrating eye injury or eye surgery. Treatment focuses on calming the immune system using corticosteroids (like prednisone) and other immunosuppressive medicines. Early diagnosis and prompt treatment are very important to protect vision. In some cases, the injured eye may need to be removed to prevent the condition from starting or worsening, though this is a difficult decision made carefully with a specialist.
Also known as:
Key symptoms:
Eye pain in one or both eyesRedness of the eyeBlurred or decreased visionSensitivity to light (photophobia)Floaters (spots or strings drifting across vision)Tearing or watery eyesHeadache around the eyesDifficulty focusingSwelling inside the eyeLoss of peripheral (side) visionSeeing halos around lights
Clinical phenotype terms (26)— hover any for plain English
Sporadic
Usually appears on its own, not inherited from a parent
Variable
Can begin at different ages, from infancy through adulthood
Treatments
No FDA-approved treatments are currently listed for Sympathetic ophthalmia.
View clinical trials →Clinical Trials
View all trials with filters →No actively recruiting trials found for Sympathetic ophthalmia at this time.
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Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Sympathetic ophthalmia.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
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Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.How quickly do I need to start treatment, and what are the risks if we wait?,What are the chances that my vision can be preserved with treatment?,What are the side effects of the medicines you are recommending, and how will we monitor for them?,How long will I need to take immunosuppressive medicines?,Should the injured eye be removed, and what are the pros and cons of that decision?,How often do I need follow-up appointments, and what warning signs should make me come in sooner?,Are there clinical trials or newer treatments I should know about?
Common questions about Sympathetic ophthalmia
What is Sympathetic ophthalmia?
Sympathetic ophthalmia (also called sympathetic uveitis or bilateral granulomatous uveitis) is a rare but serious inflammatory eye disease. It happens when one eye is injured or has surgery, and then — sometimes weeks, months, or even years later — the other, uninjured eye also becomes inflamed. The immune system mistakenly attacks both eyes as if they were foreign tissue. The injured eye is called the 'exciting eye,' and the uninjured eye that later becomes affected is called the 'sympathizing eye.' The main symptoms include eye pain, redness, blurred vision, sensitivity to light, and floate
How is Sympathetic ophthalmia inherited?
Sympathetic ophthalmia follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
Which specialists treat Sympathetic ophthalmia?
16 specialists and care centers treating Sympathetic ophthalmia are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.