Serotonin syndrome

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ORPHA:43116T43.1
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23Specialists8Treatment centers

Where are you in your journey?

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UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Also known as:

Serotonergic syndromeSerotonin stormSerotonin toxicitySerotonin toxidrome

Clinical phenotype terms— hover any for plain English:

Abnormality of the autonomic nervous systemHP:0002270RestlessnessHP:0000711InsomniaHP:0100785Abnormal saccadic eye movementsHP:0000570
Orphanet ↗NORD ↗

FDA & Trial Timeline

6 events
Mar 2026sElective Serotonin reuPtake inhibitoRs In posT-covid After COVID-19

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) — PHASE3

TrialNOT YET RECRUITING
Oct 2025Microdosing LSD in Women With Premenstrual Disorders

Friederike Holze — NA

TrialNOT YET RECRUITING
May 2025Allopregnanolone and Dynamic GABA-A Receptor Plasticity in Selective Serotonin Reuptake Inhibitor Responsive Premenstrual Dysphoric Disorder

Johns Hopkins University — PHASE4

TrialRECRUITING
Nov 2024Platelet Serotonin Deficiencies: the Strasbourg Experience

University Hospital, Strasbourg, France

TrialRECRUITING
Sep 2024Serotonin Control of Impulsivity in Tourette Disorder

Hospices Civils de Lyon — PHASE2

TrialRECRUITING
Apr 2019Effect of Serotonergic Stimulation on the Gut-brain Axis

Örebro University, Sweden — NA

TrialACTIVE NOT RECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

No FDA-approved treatments are currently listed for Serotonin syndrome.

View clinical trials →

Clinical Trials

View all trials with filters →

No actively recruiting trials found for Serotonin syndrome at this time.

New trials open frequently. Follow this disease to get notified.

Search ClinicalTrials.gov ↗Join the Serotonin syndrome community →

Specialists

23 foundView all specialists →
PM
Pablo Lapuerta, MD
SKILLMAN, NJ
Specialist
PI on 2 active trials
PM
Pablo LaPuerta, MD
SKILLMAN, NJ
Specialist
PI on 1 active trial
DM
Doug Fleming, MD
LAKE VILLAGE, AR
Specialist
PI on 1 active trial
AB
Andreas Baumbach
Specialist
PI on 1 active trial3 Serotonin syndrome publications
JB
Janine North, BS
Specialist
PI on 1 active trial
MP
Marianne Pavel, Professor
Specialist
PI on 1 active trial1 Serotonin syndrome publication
AM
Ajaykumar Morani
HOUSTON, TX
Specialist
PI on 1 active trial
AS
Anthony Shields
Specialist
PI on 2 active trials10 Serotonin syndrome publications
TM
Tom Smith, MD
Specialist
PI on 1 active trial
UM
Uri Ladabaum, M.D., M.S.
STANFORD, CA
Specialist
PI on 1 active trial
AP
Abdulghani Sankari, MD PhD
DETROIT, MI
Specialist
PI on 1 active trial
LP
Liisa Hantsoo, PhD
BALTIMORE, MD
Specialist
PI on 1 active trial
FP
Franz X Vollenweider, Prof.
Specialist
PI on 1 active trial
JP
Juan M Ocampo-Godinez, M.D., Ph.D.
Specialist
PI on 1 active trial
AM
Alan Rios-Espinosa, M.D.
Specialist
PI on 1 active trial
WM
Wayne Goodman, MD
GAINESVILLE, FL
Specialist
PI on 1 active trial1 Serotonin syndrome publication
OP
Odile Spreux-Varoquaux, PhD
Specialist
PI on 1 active trial
AD
Amy Foxx-Orenstein, DO
SCOTTSDALE, AZ
Specialist
PI on 1 active trial3 Serotonin syndrome publications
BP
Boris B Quednow, Prof
Specialist
PI on 1 active trial
CD
Catherine J Harmer, DPhil
Specialist
PI on 1 active trial
MM
Matthieu Henry-Lagarrigue, MD
Specialist
PI on 1 active trial
DM
Daniel Crail-Melendez, MD
Specialist
PI on 1 active trial
PM
Patricia Loranca-Moreno, M.D., M.Sc.
Specialist
PI on 1 active trial

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center ↗

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center ↗

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program ↗

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site ↗

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site ↗

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site ↗

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine ↗

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program ↗

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Serotonin syndrome.

Search all travel grants →NORD Financial Assistance ↗

Community

Open Serotonin syndromeForum →

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Latest news about Serotonin syndrome

Disease timeline:

New recruiting trial: Serotonin Control of Impulsivity in Tourette Disorder

A new clinical trial is recruiting patients for Serotonin syndrome

New recruiting trial: Platelet Serotonin Deficiencies: the Strasbourg Experience

A new clinical trial is recruiting patients for Serotonin syndrome

New recruiting trial: Allopregnanolone and Dynamic GABA-A Receptor Plasticity in Selective Serotonin Reuptake Inhibitor Responsive Premenstrual Dysphoric Disorder

A new clinical trial is recruiting patients for Serotonin syndrome

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Serotonin syndrome

Which specialists treat Serotonin syndrome?

23 specialists and care centers treating Serotonin syndrome are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.