Overview
Rare nevus is a term used to describe uncommon types of moles or birthmarks on the skin that do not fit into the more common categories of nevi (the medical term for moles). Nevi are growths on the skin that occur when pigment-producing cells called melanocytes cluster together. While most moles are common and harmless, rare nevi are unusual in their appearance, location, size, or behavior. They may look different from typical moles in terms of color, shape, texture, or pattern. Rare nevi can appear at birth or develop later in life. Some types may be present from the newborn period, while others emerge during childhood or adulthood. In most cases, rare nevi are benign (not cancerous), but depending on the specific type, some may carry a slightly increased risk of developing into melanoma, a serious form of skin cancer. Because of this, monitoring by a dermatologist is important. Treatment depends on the specific type of rare nevus. Many do not require treatment and are simply monitored over time with regular skin checks. If a nevus shows concerning changes in size, shape, color, or texture, a biopsy may be recommended to rule out skin cancer. Surgical removal may be considered for cosmetic reasons or if there is concern about malignant transformation. The overall outlook for most people with rare nevi is good, especially with appropriate monitoring and early intervention when needed.
Key symptoms:
Unusual-looking mole or birthmark on the skinMole with an irregular shape or borderMole with unusual coloring or multiple colorsMole with an unusual texture or surfaceMole that is larger than typical molesSkin growth that looks different from other moles on the bodyA mole that changes in size, shape, or color over timeItching or discomfort around the moleA mole in an unusual location on the bodyCosmetic concerns related to the appearance of the mole
Variable
Can be inherited in different ways depending on the underlying gene
Variable
Can begin at different ages, from infancy through adulthood
Treatments
No FDA-approved treatments are currently listed for Rare nevus.
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Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Rare nevus.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What specific type of rare nevus does my child or I have?,Does this type of nevus carry an increased risk of skin cancer?,How often should we schedule skin check-ups for monitoring?,Are there any signs or changes I should watch for at home?,Should this nevus be removed, and if so, what are the options?,Is genetic testing recommended in our case?,What sun protection measures do you recommend?
Common questions about Rare nevus
What is Rare nevus?
Rare nevus is a term used to describe uncommon types of moles or birthmarks on the skin that do not fit into the more common categories of nevi (the medical term for moles). Nevi are growths on the skin that occur when pigment-producing cells called melanocytes cluster together. While most moles are common and harmless, rare nevi are unusual in their appearance, location, size, or behavior. They may look different from typical moles in terms of color, shape, texture, or pattern. Rare nevi can appear at birth or develop later in life. Some types may be present from the newborn period, while ot
Which specialists treat Rare nevus?
11 specialists and care centers treating Rare nevus are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.