What is Rare maxillo-facial surgical disease?
Rare maxillo-facial surgical disease (Orphanet code 68329) is a broad category covering uncommon conditions that affect the bones, soft tissues, and structures of the face and jaw — including the upper jaw (maxilla), lower jaw (mandible), cheekbones, eye sockets, and surrounding areas. These conditions may be present from birth or develop over time, and they can affect how a person looks, eats, breathes, speaks, and hears. Some are caused by abnormal bone growth, while others involve tumors, cysts, or structural malformations that require surgical correction. Symptoms vary widely depending on the specific condition but often include facial asymmetry, difficulty chewing or swallowing, problems with teeth alignment (malocclusion), breathing difficulties, pain or swelling in the jaw or face, and changes in vision or hearing if nearby structures are affected. Some conditions also affect a person's self-esteem and social well-being due to visible changes in appearance. Treatment is primarily surgical and is tailored to each person's specific diagnosis. Procedures may include corrective jaw surgery (orthognathic surgery), removal of cysts or tumors, bone reconstruction, and dental rehabilitation. A team of specialists typically works together to plan and carry out care. While many of these conditions are not life-threatening, they can significantly affect quality of life, and early diagnosis and treatment generally lead to better outcomes.
Also known as:
Key symptoms:
Facial asymmetry or uneven appearance of the faceDifficulty chewing, biting, or swallowing foodTeeth that do not align properly (malocclusion or bad bite)Swelling, lumps, or growths in the jaw or facePain or tenderness in the jaw, face, or mouthDifficulty breathing, especially through the noseChanges in speech or voice qualityNumbness or tingling in the face, lips, or chinDifficulty opening or closing the mouth fullyChanges in vision if the eye socket is affectedHearing problems if structures near the ear are involvedLoose or displaced teeth without obvious dental causeVisible bone deformity or unusual facial shape
- Inheritance
- Variable
- Can be inherited in different ways depending on the underlying gene
- Age of Onset
- Variable
- Can begin at different ages, from infancy through adulthood
Treatments
Source: openFDA + DailyMed · NDA / BLA labels with structured indications · refreshed weekly
No FDA-approved treatments are currently listed for Rare maxillo-facial surgical disease.
View clinical trials →Clinical Trials
View all trials with filters →Source: ClinicalTrials.gov · synced daily · phases, status, and PI names normalized at ingest
No actively recruiting trials found for Rare maxillo-facial surgical disease at this time.
New trials open frequently. Follow this disease to get notified.
Specialists
View all specialists →Source: NPI Registry + PubMed · trial PI roles cross-referenced with ClinicalTrials.gov · ranked by match score (publications + PI activity + community signal)
No specialists are currently listed for Rare maxillo-facial surgical disease.
Treatment Centers
8 centersSource: NORD Rare Disease Centers + NIH Undiagnosed Diseases Network (UDN) · centers verified active within last 12 months
Children's Hospital Colorado Rare Disease Program ↗
Children's Hospital Colorado
📍 Aurora, CO
👤 Boston Children's Hospital Rare Disease Program
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDBoston Children's Hospital Rare Disease Program ↗
Boston Children's Hospital
📍 Boston, MA
👤 Boston Children's Hospital Rare Disease Program
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
🏨 Children'sAnn & Robert H. Lurie Children's Hospital Genetics ↗
Lurie Children's Hospital
📍 Chicago, IL
👤 Boston Children's Hospital Rare Disease Program
🏥 NORDCincinnati Children's Hospital Medical Center ↗
Cincinnati Children's
📍 Cincinnati, OH
👤 Boston Children's Hospital Rare Disease Program
🏨 Children'sNationwide Children's Hospital Rare Disease Center ↗
Nationwide Children's Hospital
📍 Columbus, OH
👤 Boston Children's Hospital Rare Disease Program
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
Travel Grants
No travel grants are currently matched to Rare maxillo-facial surgical disease.
Community
No community posts yet. Be the first to share your experience with Rare maxillo-facial surgical disease.
Start the conversation →Latest news about Rare maxillo-facial surgical disease
Source: PubMed + NIH RePORTER + openFDA + clinical-journal RSS · last 30 days · disease-tagged at ingest by AI extraction with human QC
No recent news articles for Rare maxillo-facial surgical disease.
Follow this condition to be notified when news becomes available.
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What is the specific diagnosis within the rare maxillo-facial disease category, and what does it mean for my health?,Is my condition likely to be genetic, and should other family members be evaluated?,What surgical or non-surgical treatment options are available, and what are the risks and benefits of each?,How many surgeries might I need, and what is the expected timeline for treatment?,Are there specialists or centers with specific experience in my condition that you would recommend?,How will this condition affect my ability to eat, speak, and breathe, and what support is available?,Are there clinical trials or newer treatments I should know about for my specific condition?
Common questions about Rare maxillo-facial surgical disease
What is Rare maxillo-facial surgical disease?
Rare maxillo-facial surgical disease (Orphanet code 68329) is a broad category covering uncommon conditions that affect the bones, soft tissues, and structures of the face and jaw — including the upper jaw (maxilla), lower jaw (mandible), cheekbones, eye sockets, and surrounding areas. These conditions may be present from birth or develop over time, and they can affect how a person looks, eats, breathes, speaks, and hears. Some are caused by abnormal bone growth, while others involve tumors, cysts, or structural malformations that require surgical correction. Symptoms vary widely depending on
Frequently asked questions about Rare maxillo-facial surgical disease
Auto-generated from canonical disease facts (Orphanet, OMIM, ClinicalTrials.gov, openFDA, NPPES). Not a substitute for clinical guidance.
What is Rare maxillo-facial surgical disease?
Rare maxillo-facial surgical disease is a rare disease catalogued in international rare-disease ontologies (Orphanet ORPHA:68329). It is typically inherited as variable. Age of onset is generally variable. For verified primary sources, see the UniteRare Rare maxillo-facial surgical disease page.
How is Rare maxillo-facial surgical disease inherited?
Rare maxillo-facial surgical disease follows variable inheritance. Genetic counseling is recommended for affected families to understand recurrence risk in offspring and the likelihood of unaffected siblings being carriers. Variants in the underlying gene(s) may be identified via clinical genetic testing.
Are there FDA-approved treatments for Rare maxillo-facial surgical disease?
Approved treatments for Rare maxillo-facial surgical disease are tracked from openFDA and DailyMed primary sources. Many rare diseases have no specific FDA-approved therapy; for those, supportive care and management of complications form the basis of clinical care. Orphan-drug-designation status is noted where applicable.
Are there clinical trials for Rare maxillo-facial surgical disease?
Active clinical trials for Rare maxillo-facial surgical disease are tracked daily from ClinicalTrials.gov. Trial availability changes frequently; check the UniteRare trial listings for the current count and recruitment status. Sponsors of rare-disease research often welcome inquiries even when a trial is not actively recruiting at a given moment.
How do I find a specialist for Rare maxillo-facial surgical disease?
Verified Rare maxillo-facial surgical disease specialists are identified through ClinicalTrials.gov principal-investigator records, peer-reviewed publication authorship (via PubMed), and the NPPES NPI registry. NORD-designated Centers of Excellence and NIH-affiliated rare-disease clinics are also tracked. UniteRare's specialist directory is updated continuously as new evidence becomes available.
See full Rare maxillo-facial surgical disease page for complete clinical details, sources, and verified-specialist listings.
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