Overview
Non-severe combined immunodeficiency (non-severe CID) is a rare immune system disorder where the body's defense system does not work properly, but is not completely absent as in the most serious form called severe combined immunodeficiency (SCID). In this condition, both the T cells and B cells — the white blood cells that fight infections — are reduced in number or do not function as well as they should. However, enough immune function remains that affected individuals may survive longer without treatment compared to those with SCID. People with non-severe CID are much more vulnerable to infections than healthy individuals. They may get sick more often, have infections that are harder to treat, or develop infections caused by germs that would not normally make a healthy person ill (called opportunistic infections). Common problems include repeated lung infections, chronic diarrhea, skin infections, and infections caused by viruses like cytomegalovirus (CMV) or fungi like Candida. Some people also have autoimmune problems, where the immune system mistakenly attacks the body's own tissues. Treatment depends on the specific cause and severity. Options may include immunoglobulin replacement therapy (giving antibodies through an IV or under the skin), preventive antibiotics or antifungals, and in some cases, a bone marrow or stem cell transplant. Early diagnosis and treatment are very important to prevent serious complications and improve quality of life.
Also known as:
Key symptoms:
Frequent or repeated infections (ear, lung, sinus, skin)Infections that are unusually severe or hard to treatInfections caused by unusual germs (opportunistic infections)Chronic diarrhea or stomach problemsSlow growth or failure to gain weight in childrenPersistent thrush (yeast infection in the mouth)Skin rashes or eczemaSwollen lymph nodes or enlarged spleenAutoimmune problems (immune system attacking own body)Fatigue and low energyRecurrent pneumonia or bronchitis
Variable
Can be inherited in different ways depending on the underlying gene
Variable
Can begin at different ages, from infancy through adulthood
Treatments
No FDA-approved treatments are currently listed for Non-severe combined immunodeficiency.
View clinical trials →Clinical Trials
View all trials with filters →No actively recruiting trials found for Non-severe combined immunodeficiency at this time.
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Rare Disease Specialist
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Financial Resources
1 resourcesRevcovi
Chiesi USA Inc.
Revcovi Patient Support (Chiesi Patient Support)
Travel Grants
No travel grants are currently matched to Non-severe combined immunodeficiency.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.Which specific gene is causing my (or my child's) immune deficiency, and what does that mean for treatment options?,Do I need immunoglobulin replacement therapy, and if so, which type and how often?,Should I consider a stem cell transplant, and am I (or is my child) a good candidate?,Which vaccines are safe for me (or my child) to receive?,What infections should I watch for most closely, and when should I go to the emergency room?,Are there any clinical trials or gene therapy options I should know about?,Should other family members be tested for this condition?
Common questions about Non-severe combined immunodeficiency
What is Non-severe combined immunodeficiency?
Non-severe combined immunodeficiency (non-severe CID) is a rare immune system disorder where the body's defense system does not work properly, but is not completely absent as in the most serious form called severe combined immunodeficiency (SCID). In this condition, both the T cells and B cells — the white blood cells that fight infections — are reduced in number or do not function as well as they should. However, enough immune function remains that affected individuals may survive longer without treatment compared to those with SCID. People with non-severe CID are much more vulnerable to inf
Which specialists treat Non-severe combined immunodeficiency?
16 specialists and care centers treating Non-severe combined immunodeficiency are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.
What treatment and support options exist for Non-severe combined immunodeficiency?
1 patient support program are currently tracked on UniteRare for Non-severe combined immunodeficiency. See the treatments and support programs sections for copay assistance, eligibility, and contact details.