Idiopathic panuveitis

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3Specialists8Treatment centers

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Overview

Idiopathic panuveitis is a rare inflammatory eye condition where all layers of the uvea — the middle coat of the eye — become inflamed without any identifiable underlying cause. The uvea includes the iris (the colored part of the eye), the ciliary body (which produces fluid inside the eye), and the choroid (a layer of blood vessels that nourishes the retina). When all three parts are inflamed at the same time, it is called panuveitis. The term 'idiopathic' means that doctors cannot find a specific infection, autoimmune disease, or other reason for the inflammation after thorough testing. Symptoms typically include blurred vision, eye pain, redness, sensitivity to light, and floaters (small spots or threads drifting across your vision). In some cases, vision loss can be significant if the inflammation is not controlled. The condition can affect one or both eyes and may come and go in flare-ups or become chronic. Treatment focuses on controlling inflammation and preventing complications such as cataracts, glaucoma, and permanent vision damage. Corticosteroids — given as eye drops, injections around the eye, or oral medications — are usually the first line of treatment. For patients who need long-term therapy or do not respond well to steroids, immunosuppressive drugs such as methotrexate, mycophenolate, azathioprine, or biologic agents like adalimumab may be used. Early diagnosis and consistent follow-up with an eye specialist are essential to preserving vision.

Key symptoms:

Blurred or decreased visionEye painEye rednessSensitivity to light (photophobia)Floaters (spots or threads in your vision)Tearing or watery eyesDark spots in your field of visionDifficulty seeing at nightSwelling inside the eyeHeadaches around the eyesGradual vision loss if untreated

Clinical phenotype terms (19)— hover any for plain English
Red eyeHP:0025337Vitreous hazeHP:0030652MiosisHP:0000616Posterior synechiae of the anterior chamberHP:0011484Cystoid macular edemaHP:0011505Vitreous snowballsHP:0030661Conjunctival hyperemiaHP:0030953Vitreous floatersHP:0100832Ocular hypertensionHP:0007906Choroidal neovascularizationHP:0011506Epiretinal membraneHP:0100014
Inheritance

Sporadic

Usually appears on its own, not inherited from a parent

Age of Onset

Variable

Can begin at different ages, from infancy through adulthood

Orphanet ↗NORD ↗

Treatments

No FDA-approved treatments are currently listed for Idiopathic panuveitis.

View clinical trials →

No actively recruiting trials found for Idiopathic panuveitis at this time.

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Search ClinicalTrials.gov ↗Join the Idiopathic panuveitis community →

Specialists

3 foundView all specialists →
JD
Jaap M van Laar, Prof. dr.
Specialist
PI on 1 active trial

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Idiopathic panuveitis.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Idiopathic panuveitis

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Caregiver Resources

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Questions for your doctor

Bring these to your next appointment

  • Q1.What tests have been done to rule out other causes of my uveitis, and are there any more tests I should have?,What is the best treatment plan for my specific situation, and what are the side effects I should watch for?,How often will I need follow-up eye exams to monitor my condition?,Am I at risk for complications like cataracts or glaucoma, and how will you monitor for those?,Are there any lifestyle changes I can make to help manage my symptoms or reduce flare-ups?,If my current treatment stops working, what are the next options available to me?,Should I see any other specialists, such as a rheumatologist, as part of my care?

Common questions about Idiopathic panuveitis

What is Idiopathic panuveitis?

Idiopathic panuveitis is a rare inflammatory eye condition where all layers of the uvea — the middle coat of the eye — become inflamed without any identifiable underlying cause. The uvea includes the iris (the colored part of the eye), the ciliary body (which produces fluid inside the eye), and the choroid (a layer of blood vessels that nourishes the retina). When all three parts are inflamed at the same time, it is called panuveitis. The term 'idiopathic' means that doctors cannot find a specific infection, autoimmune disease, or other reason for the inflammation after thorough testing. Symp

How is Idiopathic panuveitis inherited?

Idiopathic panuveitis follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.

Which specialists treat Idiopathic panuveitis?

3 specialists and care centers treating Idiopathic panuveitis are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.