Hyperpigmentation of the skin | UniteRare Disease Library

Overview

FDA & Trial Timeline

10 events

Jul 2026Clinical Evaluation of Microneedling Technique With Topical Application of Silymarin on Gingival Hyperpigmentation in Comparison With Diode Laser and Scalpel Methods.

Fayoum University — NA

TrialRECRUITING

Jul 2026Comparative Evaluation of Topical Metformin and Topical Tranexamic Acid in Melasma

Foundation University Islamabad — NA

TrialNOT YET RECRUITING

Jul 2026Comparative Evaluation of Topical 30% Metformin and Kligman's Regimen in Women With Melasma

Foundation University Islamabad — NA

TrialNOT YET RECRUITING

Jun 2026Expert Consensus on the Clinical Management of Melasma: A Delphi Method Study

Venus Research Center

TrialENROLLING BY INVITATION

Mar 2026Evaluation of Efficacy and Tolerabilty of MelaB3 Serum in Combination of 35% Glycolic Acid Peeling Compared to 35% Glycolic Acid Peeling Alone in Various Hyperpigmentation Conditions

Cosmetique Active International — NA

TrialNOT YET RECRUITING

Feb 2026Evaluation of the Efficacy of Oral Tranexamic Acid and Glutathione-assisted Microneedling in Treatment of Melasma

Assiut University — PHASE2, PHASE3

TrialNOT YET RECRUITING

Sep 2025An 18-week Study to Evaluate a Test Product With a Marketed Prescription Product

Good Molecules, LLC — PHASE3

TrialENROLLING BY INVITATION

Sep 2025Clinical Study to Assess Safety, Efficacy and In-Use Tolerability of Oziva Bioactive Gluta Fizzy Effervescent Tablets on Subjects With Facial Dark Spots Such as Pimple Marks, Sunspots, Age Spots and Uneven Skin Tone

NovoBliss Research Pvt Ltd — NA

TrialACTIVE NOT RECRUITING

Jul 2025The Effectiveness of a Novel Lip Product Containing Caulerpa Lentillifera Extract for Reducing Lip Hyperpigmentation

Chulalongkorn University — NA

TrialRECRUITING

Jul 2025Comparative Efficacy of Resveratrol 1 % Gel and Trichloroacetic Acid 20% in Treatment of Melasma: A Split-face Study

Assiut University — NA

TrialNOT YET RECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

No FDA-approved treatments are currently listed for Hyperpigmentation of the skin.

7 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.

View clinical trials →

Clinical Trials

7 recruitingView all trials with filters →

Phase 31 trial

An 18-week Study to Evaluate a Test Product With a Marketed Prescription Product

Phase 3

Enrolling by Invitation

· Sites: Teaneck, New Jersey · Age: 18–75 yrs

N/A5 trials

Clinical Study to Assess Safety, Efficacy and In-Use Tolerability of Oziva Bioactive Gluta Fizzy Effervescent Tablets on Subjects With Facial Dark Spots Such as Pimple Marks, Sunspots, Age Spots and Uneven Skin Tone

N/A

Active

PI: Nayan Patel (NovoBliss Research Pvt Ltd) · Sites: Ahmedabad, Gujarat · Age: 21–55 yrs

Efficacy and Tolerability of Tested Formula After 3 Months of Treatment of Facial Hyperpigmentation of 3 Origins

N/A

Actively Recruiting

PI: Steven Thng (National Skin Care Centre) · Sites: Singapore · Age: 18–99 yrs

Pilot Study of LED for PIE and PIH

N/A

Actively Recruiting

PI: Leihong Xiang, professor (Huashan Hospital) · Sites: Shanghai · Age: 20–65 yrs

The Effectiveness of a Novel Lip Product Containing Caulerpa Lentillifera Extract for Reducing Lip Hyperpigmentation

N/A

Actively Recruiting

· Sites: Bangkok · Age: 18–60 yrs

Efficacy and Tolerability of a Hybrid Fractional Laser for the Treatment of Acne Scars in Patients With Skin of Color

N/A

Actively Recruiting

PI: Kseniya Kobets, MD (Montefiore Medical Center) · Sites: Elmsford, New York · Age: 18–99 yrs

Specialists

Showing 25 of 60View all specialists →

David Zepeda, MD

Specialist

PI on 1 active trial

Active trials Directions Travel grants

Yasmine El sayed, Phd

VERNON, CT

Specialist

PI on 1 active trial

Active trials Directions Travel grants

Sally Nassar, Bds

Specialist

PI on 1 active trial

Active trials Directions Travel grants

Ravi Kumar Rajan

LAWRENCEVILLE, NJ

Specialist