Hereditary cerebral amyloid angiopathy

Last reviewed

🖨 Print for my doctorAdvocacy Hub →
ORPHA:85458OMIM:105150E85.4+I68.0*
Who is this for?
Show terms as
5Active trials7Specialists8Treatment centers

Where are you in your journey?

ℹ
UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
Report missing data

Overview

Also known as:

HCHWAHereditary cerebral hemorrhage with amyloidosis

Clinical phenotype terms— hover any for plain English:

Cerebral amyloid angiopathyHP:0011970Subarachnoid hemorrhageHP:0002138Dilation of Virchow-Robin spacesHP:0012520CSF pleocytosisHP:0012229Cerebral cortical microinfarctHP:0025714
Orphanet ↗OMIM ↗NORD ↗

FDA & Trial Timeline

7 events
Apr 2026Application of Digital Twins' Technology in Patients Who Had a Stroke, With Moyamoya Disease and With Cerebral Amyloid Angiopathy (CAA) During the Secondary Prevention Phase: A Proof of Concept Using a Randomized Control Trial (Clinical Study 6, STRATIF-AI Project)

Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta — NA

TrialRECRUITING
Dec 2025Jiedu Huayu Oral Prescription in the Treatment of Intracranial Hemorrhage Associated With Cerebral Amyloid Angiopathy

Beijing Tiantan Hospital — PHASE3

TrialNOT YET RECRUITING
Apr 2025Dilated Perivascular Spaces in the Dentate Nucleus on MRI in Patients with Hypertensive Angiopathy or Cerebral Amyloid Angiopathy

Centre Hospitalier Universitaire de Nīmes

TrialNOT YET RECRUITING
Jul 2024A Study of AMDX-2011P in Participants With CAA

Amydis Inc. — PHASE2

TrialRECRUITING
May 2024A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy

Alnylam Pharmaceuticals — PHASE2

TrialRECRUITING
Jun 2020SEarchiNg biomarkErs Cerebral Amyloid Angiopathy (SENECA)

Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta

TrialRECRUITING
Mar 2019High Frequency Imaging in Cerebral Amyloid Angiopathy

Martin Dichgans

TrialACTIVE NOT RECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

No FDA-approved treatments are currently listed for Hereditary cerebral amyloid angiopathy.

5 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.

View clinical trials →

Clinical Trials

5 recruitingView all trials with filters →
Phase 22 trials
A Study of AMDX-2011P in Participants With CAA
Phase 2
Actively Recruiting
· Sites: Phoenix, Arizona · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy
Phase 2
Actively Recruiting
PI: Medical Director (Alnylam Pharmaceuticals) · Sites: Los Angeles, California; Orange, California +55 more · Age: 30–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
N/A1 trial
Application of Digital Twins' Technology in Patients Who Had a Stroke, With Moyamoya Disease and With Cerebral Amyloid Angiopathy (CAA) During the Secondary Prevention Phase: A Proof of Concept Using a Randomized Control Trial (Clinical Study 6, STRATIF-AI Project)
N/A
Actively Recruiting
· Sites: Milan, Michigan · Age: 18–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
Other2 trials
SEarchiNg biomarkErs Cerebral Amyloid Angiopathy (SENECA)
Actively Recruiting
· Sites: Milan, Milano · Age: 55–99 yrs
View on ClinicalTrials.gov ↗I'm interested →
High Frequency Imaging in Cerebral Amyloid Angiopathy
Active
PI: Marco Duering, MD (Institute for Stroke and Dementia Research) · Sites: Bonn; Magdeburg +1 more · Age: 50–99 yrs
View on ClinicalTrials.gov ↗I'm interested →

Specialists

7 foundView all specialists →
AM
Anissa MEGZARI
Specialist
PI on 15 active trials1 Hereditary cerebral amyloid angiopathy publication
JM
JOIN-LAMBERT Claire, MD
Specialist
PI on 1 active trial
DM
David J Seiffge, Prof, MD
Specialist
PI on 2 active trials
DF
Dongsheng Fan
NEWPORT NEWS, VA
Specialist
PI on 7 active trials
AO
Anna Olczak
Specialist
PI on 1 active trial
EE
Ellis van Etten
Specialist
PI on 1 active trial
XJ
Xunming Ji
Specialist
PI on 2 active trials

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center ↗

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center ↗

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program ↗

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site ↗

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site ↗

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site ↗

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine ↗

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program ↗

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Hereditary cerebral amyloid angiopathy.

Search all travel grants →NORD Financial Assistance ↗

Community

Open Hereditary cerebral amyloid angiopathyForum →

No community posts yet. Be the first to share your experience with Hereditary cerebral amyloid angiopathy.

Start the conversation →

Latest news about Hereditary cerebral amyloid angiopathy

1 articles
Clinical trialUNITERAREApr 3, 2026
New Recruiting Trial: Application of Digital Twins' Technology in Patients Who Had a Stroke, With Moyamoya Disease and With Cerebral Amyloid Angiopathy (CAA) During the Secondary Prevention Phase: A Proof of Concept Using a Randomized Control Trial (Clinical Study 6, STRATIF-AI Project)
Researchers are testing a new technology called 'digital twins' to help prevent second strokes in patients with three rare brain conditions: moyamoya disease, c…
See all news about Hereditary cerebral amyloid angiopathy →

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Hereditary cerebral amyloid angiopathy

Are there clinical trials for Hereditary cerebral amyloid angiopathy?

Yes — 5 recruiting clinical trials are currently listed for Hereditary cerebral amyloid angiopathy on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Hereditary cerebral amyloid angiopathy?

7 specialists and care centers treating Hereditary cerebral amyloid angiopathy are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.