Overview
Glaucoma-sleep apnea syndrome is a rare condition in which two problems occur together: glaucoma (a group of eye diseases that damage the optic nerve, often due to increased pressure inside the eye) and obstructive sleep apnea (a sleep disorder where breathing repeatedly stops and starts during sleep because the airway becomes blocked). The connection between these two conditions has been recognized in medical literature, and researchers believe that the repeated drops in blood oxygen levels during sleep apnea episodes may contribute to damage of the optic nerve, worsening glaucoma. Additionally, changes in pressure inside the eye during sleep and altered blood flow to the optic nerve may play a role. Patients with this syndrome may notice gradual loss of peripheral (side) vision, blurred vision, eye pain or pressure, loud snoring, excessive daytime sleepiness, morning headaches, and difficulty concentrating. If left untreated, glaucoma can lead to permanent vision loss, and untreated sleep apnea raises the risk of heart disease, stroke, and other serious health problems. Treatment focuses on managing both conditions separately but in a coordinated way. Glaucoma is typically treated with eye drops that lower eye pressure, laser treatments, or surgery. Sleep apnea is most commonly treated with continuous positive airway pressure (CPAP) therapy, which keeps the airway open during sleep. Treating sleep apnea may also help slow the progression of glaucoma by improving oxygen delivery to the optic nerve. Regular monitoring by both an eye specialist and a sleep medicine doctor is essential.
Key symptoms:
Gradual loss of side (peripheral) visionBlurred visionEye pain or feeling of pressure in the eyeSeeing halos around lightsLoud snoringBreathing pauses during sleep witnessed by a partnerWaking up gasping or chokingExcessive daytime sleepinessMorning headachesDifficulty concentrating during the dayDry mouth upon wakingIrritability or mood changesFrequent nighttime urination
Clinical phenotype terms (3)— hover any for plain English
Multifactorial
Caused by a mix of several genes and environmental factors
Adult
Begins in adulthood (age 18 or older)
FDA & Trial Timeline
1 eventCairo University — NA
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
No FDA-approved treatments are currently listed for Glaucoma-sleep apnea syndrome.
1 clinical trialare actively recruiting — trials can provide access to cutting-edge therapies.
View clinical trials →Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Glaucoma-sleep apnea syndrome.
Community
No community posts yet. Be the first to share your experience with Glaucoma-sleep apnea syndrome.
Start the conversation →Latest news about Glaucoma-sleep apnea syndrome
Disease timeline:
New recruiting trial: Glaucoma Respsosne to Lifestyle Corrections in Sleep Apnea
A new clinical trial is recruiting patients for Glaucoma-sleep apnea syndrome
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.Could my sleep apnea be making my glaucoma worse, and how?,How often should I have my eye pressure and optic nerve checked?,Will using my CPAP machine help protect my vision?,What eye drop schedule is best for me, and are there side effects I should watch for?,Should my family members be screened for glaucoma or sleep apnea?,Are there lifestyle changes that could help both my glaucoma and sleep apnea?,What are the signs that my condition is getting worse and I need to come in sooner?
Common questions about Glaucoma-sleep apnea syndrome
What is Glaucoma-sleep apnea syndrome?
Glaucoma-sleep apnea syndrome is a rare condition in which two problems occur together: glaucoma (a group of eye diseases that damage the optic nerve, often due to increased pressure inside the eye) and obstructive sleep apnea (a sleep disorder where breathing repeatedly stops and starts during sleep because the airway becomes blocked). The connection between these two conditions has been recognized in medical literature, and researchers believe that the repeated drops in blood oxygen levels during sleep apnea episodes may contribute to damage of the optic nerve, worsening glaucoma. Additional
How is Glaucoma-sleep apnea syndrome inherited?
Glaucoma-sleep apnea syndrome follows a multifactorial inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does Glaucoma-sleep apnea syndrome typically begin?
Typical onset of Glaucoma-sleep apnea syndrome is adult. Age of onset can vary across affected individuals.
Are there clinical trials for Glaucoma-sleep apnea syndrome?
Yes — 1 recruiting clinical trial is currently listed for Glaucoma-sleep apnea syndrome on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.
Which specialists treat Glaucoma-sleep apnea syndrome?
7 specialists and care centers treating Glaucoma-sleep apnea syndrome are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.