Glaucoma-sleep apnea syndrome

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ORPHA:2085OMIM:137763H40.8
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1Active trials7Specialists8Treatment centers

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Overview

Glaucoma-sleep apnea syndrome is a rare condition in which two problems occur together: glaucoma (a group of eye diseases that damage the optic nerve, often due to increased pressure inside the eye) and obstructive sleep apnea (a sleep disorder where breathing repeatedly stops and starts during sleep because the airway becomes blocked). The connection between these two conditions has been recognized in medical literature, and researchers believe that the repeated drops in blood oxygen levels during sleep apnea episodes may contribute to damage of the optic nerve, worsening glaucoma. Additionally, changes in pressure inside the eye during sleep and altered blood flow to the optic nerve may play a role. Patients with this syndrome may notice gradual loss of peripheral (side) vision, blurred vision, eye pain or pressure, loud snoring, excessive daytime sleepiness, morning headaches, and difficulty concentrating. If left untreated, glaucoma can lead to permanent vision loss, and untreated sleep apnea raises the risk of heart disease, stroke, and other serious health problems. Treatment focuses on managing both conditions separately but in a coordinated way. Glaucoma is typically treated with eye drops that lower eye pressure, laser treatments, or surgery. Sleep apnea is most commonly treated with continuous positive airway pressure (CPAP) therapy, which keeps the airway open during sleep. Treating sleep apnea may also help slow the progression of glaucoma by improving oxygen delivery to the optic nerve. Regular monitoring by both an eye specialist and a sleep medicine doctor is essential.

Key symptoms:

Gradual loss of side (peripheral) visionBlurred visionEye pain or feeling of pressure in the eyeSeeing halos around lightsLoud snoringBreathing pauses during sleep witnessed by a partnerWaking up gasping or chokingExcessive daytime sleepinessMorning headachesDifficulty concentrating during the dayDry mouth upon wakingIrritability or mood changesFrequent nighttime urination

Clinical phenotype terms (3)— hover any for plain English
Sleep apneaHP:0010535
Inheritance

Multifactorial

Caused by a mix of several genes and environmental factors

Age of Onset

Adult

Begins in adulthood (age 18 or older)

Orphanet ↗OMIM ↗NORD ↗

FDA & Trial Timeline

1 event
Feb 2026Glaucoma Respsosne to Lifestyle Corrections in Sleep Apnea

Cairo University — NA

TrialRECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

No FDA-approved treatments are currently listed for Glaucoma-sleep apnea syndrome.

1 clinical trialare actively recruiting — trials can provide access to cutting-edge therapies.

View clinical trials →

Clinical Trials

1 recruitingView all trials with filters →
N/A1 trial
Glaucoma Respsosne to Lifestyle Corrections in Sleep Apnea
N/A
Actively Recruiting
PI: Ali MA Ismail, lecturer (Cairo University) · Sites: Giza, Dokki · Age: 3050 yrs

Specialists

7 foundView all specialists →
OP
Orna Geyer, Prof
Specialist
PI on 2 active trials
AL
Ali MA Ismail, lecturer
Specialist
PI on 5 active trials1 Glaucoma-sleep apnea syndrome publication
RM
Robert Ritch, MD
NEW YORK, NY
Specialist
PI on 3 active trials
DW
Dariusz Wozniak
Specialist
PI on 2 active trials1 Glaucoma-sleep apnea syndrome publication
DM
Dariusz Wozniak, MBBS, MRCP
Specialist
PI on 1 active trial
SO
Selim Orgül
Specialist
PI on 1 active trial

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Glaucoma-sleep apnea syndrome.

Search all travel grants →NORD Financial Assistance ↗

Community

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Latest news about Glaucoma-sleep apnea syndrome

Disease timeline:

New recruiting trial: Glaucoma Respsosne to Lifestyle Corrections in Sleep Apnea

A new clinical trial is recruiting patients for Glaucoma-sleep apnea syndrome

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Questions for your doctor

Bring these to your next appointment

  • Q1.Could my sleep apnea be making my glaucoma worse, and how?,How often should I have my eye pressure and optic nerve checked?,Will using my CPAP machine help protect my vision?,What eye drop schedule is best for me, and are there side effects I should watch for?,Should my family members be screened for glaucoma or sleep apnea?,Are there lifestyle changes that could help both my glaucoma and sleep apnea?,What are the signs that my condition is getting worse and I need to come in sooner?

Common questions about Glaucoma-sleep apnea syndrome

What is Glaucoma-sleep apnea syndrome?

Glaucoma-sleep apnea syndrome is a rare condition in which two problems occur together: glaucoma (a group of eye diseases that damage the optic nerve, often due to increased pressure inside the eye) and obstructive sleep apnea (a sleep disorder where breathing repeatedly stops and starts during sleep because the airway becomes blocked). The connection between these two conditions has been recognized in medical literature, and researchers believe that the repeated drops in blood oxygen levels during sleep apnea episodes may contribute to damage of the optic nerve, worsening glaucoma. Additional

How is Glaucoma-sleep apnea syndrome inherited?

Glaucoma-sleep apnea syndrome follows a multifactorial inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.

At what age does Glaucoma-sleep apnea syndrome typically begin?

Typical onset of Glaucoma-sleep apnea syndrome is adult. Age of onset can vary across affected individuals.

Are there clinical trials for Glaucoma-sleep apnea syndrome?

Yes — 1 recruiting clinical trial is currently listed for Glaucoma-sleep apnea syndrome on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.

Which specialists treat Glaucoma-sleep apnea syndrome?

7 specialists and care centers treating Glaucoma-sleep apnea syndrome are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.