Genetic hyperaldosteronism

Genetic hyperaldosteronism, also known as familial hyperaldosteronism, is a group of inherited conditions where the adrenal glands (small glands that sit on top of the kidneys) produce too much of a hormone called aldosterone. Aldosterone helps control blood pressure by managing the balance of salt and water in your body. When too much aldosterone is made, it causes the body to hold onto too much sodium and lose too much potassium, leading to high blood pressure and low potassium levels in the blood. There are several types of genetic hyperaldosteronism, including Type I (also called glucocorticoid-remediable aldosteronism or GRA), Type II, Type III, and Type IV. Each type is caused by changes in different genes. The most noticeable symptom across all types is high blood pressure, which can start at a young age and may be difficult to control with standard blood pressure medications. Low potassium can cause muscle weakness, cramps, fatigue, and heart rhythm problems. Treatment depends on the specific type. Type I can often be managed with low-dose glucocorticoid medications like dexamethasone, which suppress the overproduction of aldosterone. Other types may be treated with mineralocorticoid receptor antagonists such as spironolactone or eplerenone, which block the effects of aldosterone. In some cases, surgical removal of one or both adrenal glands may be considered. Early diagnosis and proper treatment are important to prevent long-term complications like heart disease, stroke, and kidney damage.

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Bring these to your next appointment

• Q1.Which type of familial hyperaldosteronism do I have, and what gene is involved?,Should my family members be tested for this condition?,What is my target blood pressure, and how often should I check it at home?,What medications are best for my specific type, and what side effects should I watch for?,How often do I need blood tests to check my potassium and kidney function?,Are there dietary changes I should make to help manage my condition?,What are the long-term risks if my blood pressure is not well controlled, and how can we minimize them?

Common questions about Genetic hyperaldosteronism

Related conditions

Other rare diseases commonly researched alongside Genetic hyperaldosteronism.

• Congenital adrenal hyperplasia→
• Liddle syndrome→