Overview
Genetic dermis disorder (Orphanet code 183472) is an extremely rare inherited condition that primarily affects the skin, specifically the dermis — the thick layer of tissue beneath the outer surface of the skin. Because this is classified as a very rare condition with limited published medical literature, detailed information about its full range of symptoms and progression is not well established. The dermis provides the skin with strength, elasticity, and structure, so disorders affecting this layer can lead to problems with skin fragility, abnormal scarring, unusual skin texture, or changes in how the skin heals after injury. Patients may notice that their skin bruises easily, stretches more than normal, or does not heal well after cuts or wounds. Treatment for genetic dermis disorders is generally supportive and focused on managing symptoms, protecting the skin from injury, and addressing complications as they arise. Because this is a genetic condition, there is currently no cure, and management typically involves a team of specialists including dermatologists and clinical geneticists. If you or your child has been diagnosed with this condition, working closely with a medical team experienced in rare skin disorders is important for the best possible care.
Key symptoms:
Fragile skin that tears or bruises easilyAbnormal skin texture or appearancePoor wound healingUnusual scarring after skin injuriesSkin that may stretch more than normalThin or translucent-looking skinEasy bruising
FDA & Trial Timeline
1 eventMayo Clinic — NA
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
No FDA-approved treatments are currently listed for Genetic dermis disorder.
View clinical trials →Clinical Trials
View all trials with filters →No actively recruiting trials found for Genetic dermis disorder at this time.
New trials open frequently. Follow this disease to get notified.
Rare Disease Specialist
Treatment Centers
8 centersMayo Clinic in Arizona
📍 Scottsdale, Arizona
Mayo Clinic in Rochester
📍 Rochester, Minnesota
Stanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
Travel Grants
No travel grants are currently matched to Genetic dermis disorder.
Community
No community posts yet. Be the first to share your experience with Genetic dermis disorder.
Start the conversation →Latest news about Genetic dermis disorder
Disease timeline:
New trial: DNA Sequencing in Clinical Practice, Mayo Clinic Health Tapestry Study
Phase NA trial recruiting. Biospecimen Collection
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What specific genetic change is causing this condition in my family?,How can we best protect the skin from injury in daily life?,What wound care products and techniques do you recommend?,Are there any clinical trials or new treatments being studied for this condition?,Should other family members be tested for this genetic condition?,What signs of complications should prompt an urgent visit?,Can you refer us to a specialist center experienced with rare skin disorders?
Common questions about Genetic dermis disorder
What is Genetic dermis disorder?
Genetic dermis disorder (Orphanet code 183472) is an extremely rare inherited condition that primarily affects the skin, specifically the dermis — the thick layer of tissue beneath the outer surface of the skin. Because this is classified as a very rare condition with limited published medical literature, detailed information about its full range of symptoms and progression is not well established. The dermis provides the skin with strength, elasticity, and structure, so disorders affecting this layer can lead to problems with skin fragility, abnormal scarring, unusual skin texture, or changes
Which specialists treat Genetic dermis disorder?
24 specialists and care centers treating Genetic dermis disorder are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.