Molecularly Determined Treatment of Diffuse Intrinsic Pontine Gliomas (DIPG)

Key facts

Sponsor

Karen D. Wright MD

Principal Investigator

Karen D. Wright, MD

Dana-Farber Cancer Institute

Intervention

Bevacizumab(drug)

Enrollment

53 enrolled

Eligibility

3-18 years · All sexes

Timeline

2011 – 2016

Study locations (23)

• Phoenix Children's Hospital, Phoenix, Arizona, United States
• Children's Hospital Los Angeles, Los Angeles, California, United States
• Stanford University/Lucile Packard Children's Hospital, Palo Alto, California, United States
• University of California, San Francisco, San Francisco, California, United States
• Children's Hospital Colorado, Aurora, Colorado, United States
• Nemours Children's Clinic, Jacksonville, Florida, United States
• Miami Children's Hospital, Miami, Florida, United States
• Children's Healthcare of Atlanta, Atlanta, Georgia, United States
• Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois, United States
• University of Louisville, Louisville, Kentucky, United States
• Johns Hopkins, Baltimore, Maryland, United States
• Dana-Farber Cancer Institute, Boston, Massachusetts, United States
• Children's Hospital of Michigan, Detroit, Michigan, United States
• Children's Hospitals and Clinics of Minnesota, Minneapolis, Minnesota, United States
• Washington University Medical Center, St Louis, Missouri, United States
• +8 more locations on ClinicalTrials.gov

Collaborators

Boston Children's Hospital · University of California, San Francisco · Ann & Robert H Lurie Children's Hospital of Chicago · Children's Healthcare of Atlanta · Children's Hospital Colorado · Children's Hospital Los Angeles · Children's Hospital of Michigan · Children's Hospitals and Clinics of Minnesota · Cook Children's Medical Center · OHSU Doernbecher Children's Hospital · Duke University · Johns Hopkins University · Nicklaus Children's Hospital f/k/a Miami Children's Hospital · Nemours Children's Clinic · New York University · Milton S. Hershey Medical Center · Seattle Children's Hospital · Lucile Packard Children's Hospital · University of Louisville · Children's National Research Institute · Washington University School of Medicine · Phoenix Children's Hospital · Medical University of South Carolina

Primary source

Recruitment status, site addresses, contacts, and full eligibility criteria can change between syncs. Always verify with the trial team before planning travel or treatment.

Other trials for Diffuse intrinsic pontine glioma

Additional recruiting or active studies for the same condition.

• RECRUITINGPHASE1NCT07076498
  Engineered HSV-1 M032 for the Treatment of Children and Adults With Newly Diagnosed Diffuse Midline Glioma After Standard of Care Radiation
  M.D. Anderson Cancer Center
• RECRUITINGPHASE1, PHASE2NCT07501156
  H3K27M-specific Immune Effector Cells Targeting DMG/DIPG
  Shenzhen Geno-Immune Medical Institute
• RECRUITINGPHASE2NCT06838676
  ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas
  Nationwide Children's Hospital
• RECRUITINGPHASE1NCT06305910
  CD200AR-L and Allogeneic Tumor Lysate Vaccine Immunotherapy for Recurrent HGG and Newly Diagnosed DMG/DIPG in Children and Young Adults
  OX2 Therapeutics
• RECRUITINGPHASE1NCT06221553
  Safety and Efficacy of Loco-regional B7H3 IL-7Ra CAR T Cell in DIPG
  Chulalongkorn University
• RECRUITINGPHASE1NCT05544526
  CAR T Cells to Target GD2 for DMG
  University College, London
• RECRUITINGPHASE1NCT05762419
  FUS Etoposide for DMG
  Columbia University
• ACTIVE NOT RECRUITINGPHASE1NCT05768880
  Study of B7-H3, EGFR806, HER2, And IL13-Zetakine (Quad) CAR T Cell Locoregional Immunotherapy For Pediatric Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, And Recurrent Or Refractory Central Nervous System Tumors
  Seattle Children's Hospital

See all trials for Diffuse intrinsic pontine glioma →