🏅 FDA Orphan Designation

Leucovorin calcium

Leucovorin

Manufacturer: Immunex Corporation

Indicated for:

Syndrome with difference of sex development of gynecological interestOrphanOsteosarcomaCongenital intrinsic factor deficiencyMethotrexate toxicityFamilial colorectal cancer Type X

FDA-Approved Indications (5)

Syndrome with difference of sex development of gynecological interestOrphan Designation

For use in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer.

Osteosarcoma

Leucovorin calcium rescue is indicated after high dose methotrexate therapy in osteosarcoma

Population: all ages

Congenital intrinsic factor deficiency

Leucovorin calcium is indicated in the treatment of megaloblastic anemias due to folic acid deficiency when oral therapy is not feasible

Population: all ages

Methotrexate toxicity

Leucovorin calcium is also indicated to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent over dosages of folic acid antagonists

Population: all ages

Familial colorectal cancer Type X

Leucovorin is also indicated for use in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer

Population: all ages

Indications & Usage

INDICATIONS AND USAGE Leucovorin calcium rescue is indicated after high dose methotrexate therapy in osteosarcoma. Leucovorin calcium is also indicated to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent over dosages of folic acid antagonists. Leucovorin calcium is indicated in the treatment of megaloblastic anemias due to folic acid deficiency when oral therapy is not feasible. Leucovorin is also indicated for use in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer. Leucovorin should not be mixed in the same infusion as 5-fluorouracil because a precipitate may form.

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LEUCOVORIN CALCIUM

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Leucovorin calcium

Immunex Corporation

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Medical disclaimer: This information is for educational purposes only. Always consult a qualified healthcare provider before making treatment decisions. Data sourced from FDA and current as of our last update.