ResearchRSSMay 6
Genetic factors may hinder treatment in Parkinson’s caused by gene: Case
A woman with early-onset Parkinson's disease caused by a VPS13C gene mutation initially improved with medication and deep brain stimulation surgery, but then got much worse over time. Her motor symptoms (movement problems) and nonmotor symptoms (like mood or sleep issues) worsened rapidly, eventually making it impossible for her to live on her own. This case suggests that genetic causes of Parkinson's disease may affect how well standard treatments work.
WHY IT MATTERSIf you have VPS13C-related Parkinson's disease, this case shows that standard treatments like deep brain stimulation may not work as well long-term, so you should discuss genetic testing and personalized treatment plans with your neurologist.