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NewsTHE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISMMonday, March 16, 2026 · March 16, 2026

MECP2 Rare Variants in Boys With Central Precocious Puberty.

WHY IT MATTERS

Recent peer-reviewed research on Rare central precocious puberty that may be relevant for patients and caregivers.

Central precocious puberty (CPP) has strong genetic and epigenetic influences. MECP2, an X-linked gene, encodes a DNA methylation reader with a role in gene transcription regulation. MECP2 loss-of-function mutations are linked to neurodevelopmental disorders, particularly with Rett syndrome, a sever...

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Read the original at The Journal of clinical endocrinology and metabolism
ResearchPubMedRare central precocious pubertyHumansMethyl-CpG-Binding Protein 2

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Rare central precocious puberty

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