NewsCANCER DISCOVERYSunday, May 17, 2026 · 6 days ago
SPEN loss drives extra-follicular diffuse large B cell lymphoma with female-specific lethality and therapeutic vulnerabilities.
WHY IT MATTERS
Recent peer-reviewed research on Diffuse large B-cell lymphoma that may be relevant for patients and caregivers.
Diffuse large B-cell lymphomas (DLBCL) are genetically and phenotypically heterogeneous, making diagnosis and treatment challenging. Current models suggest DLBCL derive from follicular B cells engaged in adaptive immune responses. By studying co-occurring truncating mutations in SPEN and NOTCH2 in t...
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