NewsINTERNATIONAL JOURNAL OF HEMATOLOGYSunday, February 8, 2026 · February 8, 2026
Clonal expansion mechanisms in paroxysmal nocturnal hemoglobinuria.
WHY IT MATTERS
Recent peer-reviewed research on Paroxysmal nocturnal hemoglobinuria that may be relevant for patients and caregivers.
Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by complement-dependent intravascular hemolysis and thrombosis as well as bone marrow failure. Complement dysregulation occurs as a result of defective cell surface expression of two glycosylphosphatidylinositol (GPI)-anchored complement reg...
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