NewsEUROPEAN JOURNAL OF MEDICINAL CHEMISTRYFriday, January 23, 2026 · January 23, 2026
Neutral sp 2 -iminosugars exploiting non-glycone interactions for selective acid α- and β-glucosidase activity modulation: Pharmacological chaperones for Gaucher and Pompe diseases.
WHY IT MATTERS
Recent peer-reviewed research on Gaucher disease that may be relevant for patients and caregivers.
A major challenge in developing selective active site-directed pharmacological chaperones for lysosomal storage disorders is discriminating among glycosidases acting on anomeric substrates. Here, we report the design and synthesis of neutral thiourea-type sp 2 -iminosugars derived from 1-deoxynojiri...
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