NewsJOURNAL OF CYSTIC FIBROSIS : OFFICIAL JOURNAL OF THE EUROPEAN CYSTIC FIBROSIS SOCIETYMonday, March 23, 2026 · March 23, 2026
CFTR correctors potentiate gating mutants causing cystic fibrosis.
WHY IT MATTERS
Recent peer-reviewed research on Cystic fibrosis that may be relevant for patients and caregivers.
The Cystic Fibrosis Transmembrane conductance Regulator (CFTR) modulator VX-445 (Elexacaftor) used to treat cystic fibrosis presents both corrector and potentiator activities. This drug binds to a pocket within the CFTR membrane-spanning domain (MSD) assembly, in contact with the lasso motif. We hav...
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