NewsSIGNAL TRANSDUCTION AND TARGETED THERAPYWednesday, April 1, 2026 · April 1, 2026
Glucocorticoids elevate clear cell renal cell carcinoma sensitivity to HIF-2α inhibitors by suppressing H4K12 lactylation.
WHY IT MATTERS
Recent peer-reviewed research on Renal cell carcinoma that may be relevant for patients and caregivers.
Approximately 70% of clear cell renal cell carcinoma (ccRCC) patients harbor von Hippel‒Lindau (VHL) deficiency, which drives pseudohypoxia and metabolic reprogramming. Here, we report a histone H4 lysine 12 lactylation (H4K12la)-fueled phosphoglycerate kinase 1 (PGK1)-lactate positive feedba...
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