NewsANNALS OF SURGICAL ONCOLOGYFriday, February 13, 2026 · February 13, 2026
Germline BRCA1/2 Mutation Prevalence in Unselected ER-Low/HER2-Negative Breast Cancer.
WHY IT MATTERS
Recent peer-reviewed research on Hereditary breast cancer that may be relevant for patients and caregivers.
Estrogen receptor (ER)-low breast cancers, defined as tumors with 1-10% ER expression, exhibit clinicopathologic and molecular features, as well as chemotherapy responses, resembling triple-negative breast cancer (TNBC), leading to updated guidelines. However, current BRCA1/2 testing guidelines clas...
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