NewsJAMA CARDIOLOGYWednesday, February 11, 2026 · February 11, 2026
Anti-ANGPTL3 Antibody SHR-1918 for Homozygous Familial Hypercholesterolemia: A Nonrandomized Clinical Trial.
WHY IT MATTERS
Recent peer-reviewed research on Homozygous familial hypercholesterolemia that may be relevant for patients and caregivers.
Homozygous familial hypercholesterolemia (HoFH) is a rare, life-threatening genetic disorder. Patients with HoFH have markedly elevated low-density lipoprotein cholesterol (LDL-C) levels from birth, and their activity of LDL receptor (LDLR) is typically absent or severely impaired. However, efficacy...
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