NewsMOLECULAR THERAPY : THE JOURNAL OF THE AMERICAN SOCIETY OF GENE THERAPYThursday, April 2, 2026 · April 2, 2026
CD96 as a therapeutic target for CAR T cell therapy in acute myeloid leukemia.
WHY IT MATTERS
Recent peer-reviewed research on Acute myeloid leukemia that may be relevant for patients and caregivers.
Therapies leveraging chimeric antigen receptor (CAR) T cells for acute myeloid leukemia (AML) are limited by the scarcity of leukemia stem cell (LSC)-specific antigens. Here, we found that CD96 is expressed in 48.3% of AML patients, with higher expression on LSCs than blasts, and is absent on normal...
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