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Clinical trialUNITERARESunday, April 5, 2026 · April 5, 2026

New Recruiting Trial: Natural History of Dysregulation and Aging of the Immune System in People With Trisomy 21 With and Without Thymectomy

WHY IT MATTERS

This trial is now recruiting people with Down syndrome to help researchers understand immune system problems that affect this population — findings could lead to better treatments for infections and other immune conditions common in Trisomy 21.

Researchers are looking for people with Down syndrome (Trisomy 21) to join a study about how their immune system works differently and ages over time. Some participants will have had their thymus gland removed, while others won't have, so scientists can compare how this affects immune health. The study will help doctors understand why people with Down syndrome often get more infections and have other immune-related health problems.

NCT ID: NCT07416201 Title: Natural History of Dysregulation and Aging of the Immune System in People With Trisomy 21 With and Without Thymectomy Status: RECRUITING Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Start date: 2026-04-05 URL: https://clinicaltrials.gov/study/NCT07416201 Source: UniteRare clinical trials database

YOU CAN ACT ON THIS

If you or a family member has Down syndrome, check the trial website (clinicaltrials.gov/study/NCT07416201) to see if you meet eligibility requirements and contact the research team to learn about enrollment.

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down syndromeimmune systemclinical trialnatural history studythymectomy

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