NewsACR OPEN RHEUMATOLOGYTuesday, March 24, 2026 · March 24, 2026
Methotrexate Therapy in Juvenile Idiopathic Arthritis: No Clinically Relevant Pulmonary Impairment but Frequent Transient Liver Enzyme Elevations in a Longitudinal Single-Center Pediatric Cohort of 274 Children Over 30 Years.
WHY IT MATTERS
Recent peer-reviewed research on Juvenile idiopathic arthritis that may be relevant for patients and caregivers.
Methotrexate (MTX) is a cornerstone in treating juvenile idiopathic arthritis (JIA). The long-term impact of MTX, particularly on pulmonary and liver function, remains a concern. We longitudinally examined the effects of MTX on pulmonary and hepatic function in the largest reported cohort to date. I...
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