Overview
T-cell/histiocyte rich large B cell lymphoma (THRLBCL) is a rare and aggressive type of non-Hodgkin lymphoma, which is a cancer of the immune system. In this disease, cancerous large B cells (a type of white blood cell) are found scattered among a background of many normal T cells and histiocytes (another type of immune cell). This unusual mix of cells can make diagnosis challenging because it can look similar to other conditions under the microscope. THRLBCL most commonly affects middle-aged adults, and men are diagnosed more often than women. Patients typically present with advanced-stage disease, often with involvement of the lymph nodes, spleen, liver, and bone marrow. Common symptoms include painless swelling of lymph nodes, unexplained fevers, drenching night sweats, unintended weight loss, and fatigue. Because the disease is often widespread at diagnosis, it tends to have a more aggressive course compared to some other types of large B cell lymphoma. Treatment usually involves combination chemotherapy, most commonly the R-CHOP regimen (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone). While many patients respond to initial treatment, THRLBCL can be harder to treat than typical diffuse large B cell lymphoma, and relapse rates may be higher. Some patients may need more intensive chemotherapy or stem cell transplantation. Early and accurate diagnosis is important for the best possible outcomes.
Also known as:
Key symptoms:
Painless swollen lymph nodesUnexplained feversDrenching night sweatsUnintended weight lossSevere fatigue and tirednessEnlarged spleenEnlarged liverBone marrow involvement causing low blood countsAnemia leading to paleness and weaknessEasy bruising or bleedingFrequent infectionsLoss of appetiteAbdominal fullness or discomfort
Sporadic
Usually appears on its own, not inherited from a parent
Adult
Begins in adulthood (age 18 or older)
Treatments
No FDA-approved treatments are currently listed for T-cell/histiocyte rich large B cell lymphoma.
View clinical trials →Clinical Trials
View all trials with filters →No actively recruiting trials found for T-cell/histiocyte rich large B cell lymphoma at this time.
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Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to T-cell/histiocyte rich large B cell lymphoma.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
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Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What stage is my lymphoma, and has it spread to the bone marrow or other organs?,Is R-CHOP the best treatment option for my specific situation, or should I consider a clinical trial?,What are the expected side effects of treatment, and how can they be managed?,How will we know if the treatment is working, and how often will I need scans?,What happens if the lymphoma does not respond to the first treatment or comes back?,Am I a candidate for stem cell transplantation or CAR-T cell therapy if needed?,Are there any lifestyle changes I should make during and after treatment to support my recovery?
Common questions about T-cell/histiocyte rich large B cell lymphoma
What is T-cell/histiocyte rich large B cell lymphoma?
T-cell/histiocyte rich large B cell lymphoma (THRLBCL) is a rare and aggressive type of non-Hodgkin lymphoma, which is a cancer of the immune system. In this disease, cancerous large B cells (a type of white blood cell) are found scattered among a background of many normal T cells and histiocytes (another type of immune cell). This unusual mix of cells can make diagnosis challenging because it can look similar to other conditions under the microscope. THRLBCL most commonly affects middle-aged adults, and men are diagnosed more often than women. Patients typically present with advanced-stage d
How is T-cell/histiocyte rich large B cell lymphoma inherited?
T-cell/histiocyte rich large B cell lymphoma follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does T-cell/histiocyte rich large B cell lymphoma typically begin?
Typical onset of T-cell/histiocyte rich large B cell lymphoma is adult. Age of onset can vary across affected individuals.
Which specialists treat T-cell/histiocyte rich large B cell lymphoma?
14 specialists and care centers treating T-cell/histiocyte rich large B cell lymphoma are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.