Supernumerary breasts

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20Specialists8Treatment centers

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UniteRare data is sourced from FDA.gov, ClinicalTrials.gov, Orphanet, OMIM, and NORD.
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Overview

Supernumerary breasts, also known as polymastia or accessory breasts, is a congenital condition in which one or more additional breast tissues develop along the embryonic mammary ridge (milk line), which extends from the axilla (armpit) to the groin on both sides of the body. This condition results from incomplete regression of the mammary ridge during fetal development. The extra breast tissue may range from a small amount of glandular tissue without a visible nipple to a fully formed accessory breast with a nipple and areola. The most common location for supernumerary breasts is the axillary (underarm) region or just below the normal breast on the chest or abdomen. The condition affects the integumentary system and, in some cases, the underlying soft tissues of the chest or abdominal wall. Supernumerary breasts are usually present from birth but may become more noticeable during puberty, pregnancy, or lactation, when hormonal changes cause the accessory tissue to enlarge, become tender, or even produce milk. In most cases, the condition is benign and asymptomatic, though it can cause cosmetic concerns, discomfort, or psychological distress. Importantly, accessory breast tissue is subject to the same pathological conditions as normal breast tissue, including fibroadenomas, cysts, and, rarely, breast carcinoma. Therefore, clinical surveillance may be recommended, particularly if the tissue is glandular. Treatment is generally not required unless the individual experiences symptoms, cosmetic concerns, or complications. Surgical excision is the standard treatment when intervention is desired, and it is typically curative. Supernumerary breasts can occur as an isolated finding or, less commonly, in association with other congenital anomalies, including renal or urinary tract malformations, though this association remains debated in the literature.

Also known as:

Inheritance

Variable

Can be inherited in different ways depending on the underlying gene

Age of Onset

Neonatal

Begins at or shortly after birth (first 4 weeks)

Orphanet ↗NORD ↗

FDA & Trial Timeline

3 events
May 2025Sensitivity of Organoids to Predict Treatment Outcome in Breast Cancer Metastases

King's College London

TrialRECRUITING
Dec 2020Motiva Flora Tissue Expander PMCF

Establishment Labs — NA

TrialRECRUITING
May 2020Lifestyles and Breast Cancer

University of Navarra — NA

TrialACTIVE NOT RECRUITING

Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.

Treatments

No FDA-approved treatments are currently listed for Supernumerary breasts.

View clinical trials →

No actively recruiting trials found for Supernumerary breasts at this time.

New trials open frequently. Follow this disease to get notified.

Search ClinicalTrials.gov ↗Join the Supernumerary breasts community →

Specialists

20 foundView all specialists →
LM
Laurent Mortier, MD,PhD
Specialist
PI on 2 active trials
AG
Agustin Garcia
MISSOULA, MT
Specialist
PI on 5 active trials108 Supernumerary breasts publications
SD
Siham Dikhaye
Specialist
1 Supernumerary breasts publication
GC
Ghita Cherkaoui
Specialist
1 Supernumerary breasts publication
AO
Ayat Allah Oufkir
Specialist
1 Supernumerary breasts publication
NZ
Nada Zizi
Specialist
1 Supernumerary breasts publication
KS
Kaoutar Sof
Specialist
1 Supernumerary breasts publication
HS
Hasnae Saddouk
Specialist
1 Supernumerary breasts publication
HD
Hanane Daflaoui
Specialist
1 Supernumerary breasts publication
AK
Anthony Kong
SACRAMENTO, CA
Specialist
PI on 1 active trial9 Supernumerary breasts publications
TP
Trinidad Dierssen-Sotos, MD, PhD
Specialist
PI on 1 active trial
AM
Atif Khan, MD
Specialist
PI on 1 active trial
JP
Jose J Jimenez-Moleon, MD, PhD
Specialist
PI on 1 active trial
MP
Marina Pollan, Md, PhD
Specialist
PI on 1 active trial
EP
Estefania A Toledo, MD, MPH, PhD
Specialist
PI on 1 active trial
RP
Rachel Blitzblau, MD PhD
DURHAM, NC
Specialist
PI on 1 active trial
MM
Mary C Mahoney, MD
Specialist
PI on 1 active trial
BP
Bruce J Tromberg, Ph.D
Specialist
PI on 2 active trials
AM
Amy Argus, MD
COLUMBUS, OH
Specialist
PI on 1 active trial1 Supernumerary breasts publication
MD
MARÍA TORRES-LACOMBA, DOCTOR
Specialist
PI on 1 active trial

Treatment Centers

8 centers
🏥 NORD

Baylor College of Medicine Rare Disease Center

Baylor College of Medicine

📍 Houston, TX

🏥 NORD

Stanford Medicine Rare Disease Center

Stanford Medicine

📍 Stanford, CA

🔬 UDN

NIH Clinical Center Undiagnosed Diseases Program

National Institutes of Health

📍 Bethesda, MD

🔬 UDN

UCLA UDN Clinical Site

UCLA Health

📍 Los Angeles, CA

🔬 UDN

Baylor College of Medicine UDN Clinical Site

Baylor College of Medicine

📍 Houston, TX

🔬 UDN

Harvard/MGH UDN Clinical Site

Massachusetts General Hospital

📍 Boston, MA

🏥 NORD

Mayo Clinic Center for Individualized Medicine

Mayo Clinic

📍 Rochester, MN

👤 Mayo Clinic Center for Individualized Medicine

🏥 NORD

UCLA Rare Disease Day Program

UCLA Health

📍 Los Angeles, CA

Travel Grants

No travel grants are currently matched to Supernumerary breasts.

Search all travel grants →NORD Financial Assistance ↗

Community

Open Supernumerary breastsForum →

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Latest news about Supernumerary breasts

Disease timeline:

New recruiting trial: Sensitivity of Organoids to Predict Treatment Outcome in Breast Cancer Metastases

A new clinical trial is recruiting patients for Supernumerary breasts

New recruiting trial: Motiva Flora Tissue Expander PMCF

A new clinical trial is recruiting patients for Supernumerary breasts

Caregiver Resources

NORD Caregiver Resources

Support, advocacy, and financial assistance for caregivers of rare disease patients.

Mental Health Support

Rare disease caregiving can be isolating. Connect with counseling and peer support.

Family & Caregiver Grants

Financial assistance programs specifically for caregivers of rare disease patients.

Social Security Disability

Learn how rare disease patients may qualify for SSDI/SSI benefits.

Common questions about Supernumerary breasts

What is Supernumerary breasts?

Supernumerary breasts, also known as polymastia or accessory breasts, is a congenital condition in which one or more additional breast tissues develop along the embryonic mammary ridge (milk line), which extends from the axilla (armpit) to the groin on both sides of the body. This condition results from incomplete regression of the mammary ridge during fetal development. The extra breast tissue may range from a small amount of glandular tissue without a visible nipple to a fully formed accessory breast with a nipple and areola. The most common location for supernumerary breasts is the axillary

At what age does Supernumerary breasts typically begin?

Typical onset of Supernumerary breasts is neonatal. Age of onset can vary across affected individuals.

Which specialists treat Supernumerary breasts?

20 specialists and care centers treating Supernumerary breasts are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.