Overview
Orphanet code 423662 refers to a rare disorder of the autonomic nervous system — the part of your nervous system that controls automatic body functions you do not have to think about, like heart rate, blood pressure, digestion, sweating, and breathing. When this system does not work properly, many different parts of the body can be affected at the same time, which can make the condition hard to recognize and diagnose. People with this type of disorder may experience dizziness when standing up, an unusually fast or slow heart rate, problems with digestion, difficulty regulating body temperature, and episodes of fainting. Because the autonomic nervous system touches so many body systems, symptoms can seem unrelated at first, leading to delays in getting the right diagnosis. The exact name and any common synonyms for this specific Orphanet entry are not fully established in publicly available sources at this time, which reflects how rare and incompletely characterized this condition is. Treatment is generally focused on managing individual symptoms rather than curing the underlying cause. A team of specialists — often including neurologists and cardiologists — typically works together to help patients maintain the best possible quality of life. Research into autonomic nervous system disorders is ongoing, and new therapies are being explored.
Key symptoms:
Dizziness or lightheadedness when standing upFainting or near-fainting episodesUnusually fast, slow, or irregular heartbeatProblems with digestion such as nausea, bloating, or constipationDifficulty regulating body temperatureExcessive or reduced sweatingBlurred vision when changing positionsFatigue and low energyBladder problems such as difficulty urinating or frequent urinationDry eyes or dry mouth
FDA & Trial Timeline
10 eventsCNSystems Medizintechnik GmbH
Boston Scientific Corporation
University Medical Centre Ljubljana
Xuanwu Hospital, Beijing
CuraSen Therapeutics, Inc. — PHASE2
Kessler Foundation — NA
Gérond'if — NA
University of British Columbia — NA
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
No FDA-approved treatments are currently listed for Rare autonomic nervous system disorder.
19 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.
View clinical trials →Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Rare autonomic nervous system disorder.
Community
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What specific type of autonomic nervous system disorder do I have, and what is known about its cause?,Should I have genetic testing, and could this condition affect other family members?,What tests do you recommend to understand how severely my autonomic system is affected?,What lifestyle changes — such as diet, fluid intake, or exercise — can help manage my symptoms?,Are there any medications that might help, and what are the risks and benefits?,What symptoms should prompt me to go to the emergency room?,Are there any clinical trials or research studies I might be eligible to join?
Common questions about Rare autonomic nervous system disorder
What is Rare autonomic nervous system disorder?
Orphanet code 423662 refers to a rare disorder of the autonomic nervous system — the part of your nervous system that controls automatic body functions you do not have to think about, like heart rate, blood pressure, digestion, sweating, and breathing. When this system does not work properly, many different parts of the body can be affected at the same time, which can make the condition hard to recognize and diagnose. People with this type of disorder may experience dizziness when standing up, an unusually fast or slow heart rate, problems with digestion, difficulty regulating body temperature
Are there clinical trials for Rare autonomic nervous system disorder?
Yes — 19 recruiting clinical trials are currently listed for Rare autonomic nervous system disorder on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.
Which specialists treat Rare autonomic nervous system disorder?
2 specialists and care centers treating Rare autonomic nervous system disorder are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.