Overview
Pancreatic solid pseudopapillary neoplasm (SPN), also called solid pseudopapillary tumor (SPT) or Frantz tumor, is a rare type of pancreatic tumor. Unlike most pancreatic cancers, this tumor tends to grow slowly and is usually considered low-grade, meaning it is not as aggressive as other pancreatic cancers. It gets its name from how it looks under a microscope — it has both solid and papillary (finger-like) structures mixed together. This tumor most commonly affects young women, especially those in their teens, twenties, and thirties. It can grow in any part of the pancreas — the head, body, or tail. As the tumor grows, it may press on nearby organs and cause symptoms like belly pain, a feeling of fullness, or a lump you can feel in the abdomen. Many people are diagnosed by accident when imaging is done for another reason. The good news is that surgery to remove the tumor is usually curative. Most people who have the tumor fully removed do very well long-term. In rare cases, the tumor can spread to the liver or nearby tissues, but even then, treatment options exist. Overall, the outlook for this condition is much better than for most other pancreatic tumors.
Also known as:
Key symptoms:
Dull or aching pain in the upper belly or abdomenA feeling of fullness or bloating after eating small amountsA lump or mass you can feel in the abdomenNausea or vomitingUnexplained weight lossLoss of appetiteBack painFatigue or tirednessJaundice (yellowing of the skin or eyes) if the tumor blocks the bile ductAccidental discovery on imaging done for another reason (no symptoms at all)
Sporadic
Usually appears on its own, not inherited from a parent
Juvenile
Begins in the teen years
FDA & Trial Timeline
10 eventsRWTH Aachen University
The First Affiliated Hospital with Nanjing Medical University — EARLY_PHASE1
Dong Zhang — NA
Fudan University
Fudan University — PHASE2
China-Japan Friendship Hospital — NA
University Hospital, Geneva
Guangdong Provincial People's Hospital
Vanderbilt University Medical Center — NA
ChromX Health
Data sourced from FDA regulatory filings and ClinicalTrials.gov. Updated periodically.
Treatments
No FDA-approved treatments are currently listed for Pancreatic solid pseudopapillary neoplasm.
3 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.
View clinical trials →Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Pancreatic solid pseudopapillary neoplasm.
Community
No community posts yet. Be the first to share your experience with Pancreatic solid pseudopapillary neoplasm.
Start the conversation →Latest news about Pancreatic solid pseudopapillary neoplasm
Disease timeline:
New recruiting trial: An Exploratory Clinical Study on the Safety and Efficacy of Autologous NK Cells in the Treatment of Pulmonary Nodules
A new clinical trial is recruiting patients for Pancreatic solid pseudopapillary neoplasm
New recruiting trial: In-depth Analysis of the Immune Responses in the Upper Respiratory Tract in Older Adults Infected or Colonized With Streptococcus Pneumoniae (Spn)
A new clinical trial is recruiting patients for Pancreatic solid pseudopapillary neoplasm
New recruiting trial: A Trial to Compare Robotic Assisted Bronchoscopy Ion's Clinical Utility for Peripheral Lung Nodule Access and Diagnosis to ENB
A new clinical trial is recruiting patients for Pancreatic solid pseudopapillary neoplasm
New recruiting trial: DOLCE: Determining the Impact of Optellum's Lung Cancer Prediction Solution
A new clinical trial is recruiting patients for Pancreatic solid pseudopapillary neoplasm
New recruiting trial: Plasma Metabolomics as a Tool to Distinguish PET-positive Malignant From PET-positive Benign Nodules
A new clinical trial is recruiting patients for Pancreatic solid pseudopapillary neoplasm
New recruiting trial: Biomarkers for Risk Stratification in Lung Cancer
A new clinical trial is recruiting patients for Pancreatic solid pseudopapillary neoplasm
New recruiting trial: The Effect of the Timing of Supplemental Parenteral Nutrition on the Prognosis of Critically Ill Patients (T-SPN)
A new clinical trial is recruiting patients for Pancreatic solid pseudopapillary neoplasm
New recruiting trial: Differentiation of Benign and Malignant Pulmonary Nodules by Volatile Organic Compounds in Human Exhaled Breath
A new clinical trial is recruiting patients for Pancreatic solid pseudopapillary neoplasm
New recruiting trial: Assessment of a Radiomics-based Computer-Aided Diagnosis Tool for Pulmonary nodulES
A new clinical trial is recruiting patients for Pancreatic solid pseudopapillary neoplasm
New recruiting trial: Virtual Bronchoscopic Navigation to Increase Diagnostic Yield in Patients With Pulmonary Nodules
A new clinical trial is recruiting patients for Pancreatic solid pseudopapillary neoplasm
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.Is my tumor completely removable with surgery, and what type of surgery do you recommend?,What are the risks of surgery, and how long will recovery take?,Will I need any additional treatment like chemotherapy or radiation after surgery?,How often will I need follow-up scans, and what are you looking for?,Could removing part of my pancreas affect my digestion or cause diabetes?,What are the chances the tumor could come back, and what would we do if it does?,Should I be seen at a specialized pancreatic cancer center for my care?
Common questions about Pancreatic solid pseudopapillary neoplasm
What is Pancreatic solid pseudopapillary neoplasm?
Pancreatic solid pseudopapillary neoplasm (SPN), also called solid pseudopapillary tumor (SPT) or Frantz tumor, is a rare type of pancreatic tumor. Unlike most pancreatic cancers, this tumor tends to grow slowly and is usually considered low-grade, meaning it is not as aggressive as other pancreatic cancers. It gets its name from how it looks under a microscope — it has both solid and papillary (finger-like) structures mixed together. This tumor most commonly affects young women, especially those in their teens, twenties, and thirties. It can grow in any part of the pancreas — the head, body,
How is Pancreatic solid pseudopapillary neoplasm inherited?
Pancreatic solid pseudopapillary neoplasm follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does Pancreatic solid pseudopapillary neoplasm typically begin?
Typical onset of Pancreatic solid pseudopapillary neoplasm is juvenile. Age of onset can vary across affected individuals.
Are there clinical trials for Pancreatic solid pseudopapillary neoplasm?
Yes — 3 recruiting clinical trials are currently listed for Pancreatic solid pseudopapillary neoplasm on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.
Which specialists treat Pancreatic solid pseudopapillary neoplasm?
8 specialists and care centers treating Pancreatic solid pseudopapillary neoplasm are listed on UniteRare, sourced from ClinicalTrials.gov principal investigators, published research, and the NPPES NPI registry.