Overview
Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome is a very rare genetic condition that affects multiple parts of the body, especially the face, mouth, and brain development. The name describes the main features: problems with the roof of the mouth (palate), teeth that are spaced farther apart than usual, distinctive facial features, and delays in reaching developmental milestones like talking and learning. This condition is sometimes referred to by its Orphanet code ORPHA:477993 and falls under the broader category of rare multiple congenital anomaly syndromes. Children with this syndrome may have a high-arched or cleft palate, which can make feeding and speech more difficult. The widely spaced teeth and unique facial features are usually noticeable from birth or early infancy. Developmental delays can range from mild to moderate and often affect both intellectual development and speech. Some children may also have other physical differences that vary from person to person. Treatment focuses on managing individual symptoms rather than curing the underlying condition. A team of specialists typically works together to support the child's growth, learning, and quality of life. Early intervention with speech therapy, educational support, and dental care can make a meaningful difference in daily functioning and long-term outcomes.
Key symptoms:
High-arched or cleft palate (problems with the roof of the mouth)Widely spaced teethDistinctive facial features such as unusual spacing of the eyes or shape of the noseDelays in learning and intellectual developmentSpeech and language delaysFeeding difficulties in infancyShort stature or slow growthBehavioral differences
Clinical phenotype terms (42)— hover any for plain English
Autosomal dominant
Passed on from just one parent; each child has about a 50% chance of inheriting it
Neonatal
Begins at or shortly after birth (first 4 weeks)
Treatments
No FDA-approved treatments are currently listed for Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome.
View clinical trials →Clinical Trials
View all trials with filters →No actively recruiting trials found for Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome at this time.
New trials open frequently. Follow this disease to get notified.
Specialists
View all specialists →No specialists are currently listed for Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome.
Community
No community posts yet. Be the first to share your experience with Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome.
Start the conversation →Latest news about Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome
No recent news articles for Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome.
Follow this condition to be notified when news becomes available.
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What genetic tests should my child have to confirm this diagnosis and identify the specific gene involved?,Does my child need surgery for the palate, and if so, when is the best time to do it?,What therapies should we start right away, and how often should my child receive them?,What developmental milestones should I watch for, and when should I be concerned?,Are there other family members who should be tested for this condition?,What educational supports should we put in place before my child starts school?,Are there any clinical trials or research studies we could participate in?
Common questions about Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome
What is Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome?
Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome is a very rare genetic condition that affects multiple parts of the body, especially the face, mouth, and brain development. The name describes the main features: problems with the roof of the mouth (palate), teeth that are spaced farther apart than usual, distinctive facial features, and delays in reaching developmental milestones like talking and learning. This condition is sometimes referred to by its Orphanet code ORPHA:477993 and falls under the broader category of rare multiple congenital anomaly syndro
How is Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome inherited?
Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome follows a autosomal dominant inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome typically begin?
Typical onset of Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome is neonatal. Age of onset can vary across affected individuals.