What is OBSOLETE: Vascular malposition?
Vascular malposition is a term that was previously used in medical records and older classification systems to describe a group of heart and blood vessel defects present at birth, where the major blood vessels leaving the heart are not in their correct positions. This entry is now considered 'obsolete' in current medical databases, meaning the term has been retired and replaced by more specific, modern diagnoses. The conditions it once described — such as transposition of the great arteries, double outlet right ventricle, or other conotruncal heart defects — involve the aorta and pulmonary artery being switched, misaligned, or otherwise abnormally positioned. These structural problems mean the heart cannot pump blood efficiently to the lungs and body. Babies born with these conditions often show signs of low oxygen levels (bluish skin color), rapid breathing, and poor feeding shortly after birth. Today, these conditions are diagnosed using echocardiography (heart ultrasound) and treated with open-heart surgery, often in the newborn period. Outcomes have improved dramatically with modern surgical techniques, and many children go on to live full lives with appropriate follow-up care.
Key symptoms:
Bluish or grayish skin color (cyanosis) due to low oxygenRapid or labored breathingPoor feeding or tiring easily during feedingFast heart rateSwelling in the legs, belly, or around the eyesPale or grayish skin toneFailure to gain weight normallyHeart murmur detected by a doctorFainting or collapse in severe cases
- Inheritance
- Variable
- Can be inherited in different ways depending on the underlying gene
- Age of Onset
- Neonatal
- Begins at or shortly after birth (first 4 weeks)
Treatments
Source: openFDA + DailyMed · NDA / BLA labels with structured indications · refreshed weekly
No FDA-approved treatments are currently listed for OBSOLETE: Vascular malposition.
View clinical trials →Clinical Trials
View all trials with filters →Source: ClinicalTrials.gov · synced daily · phases, status, and PI names normalized at ingest
No actively recruiting trials found for OBSOLETE: Vascular malposition at this time.
New trials open frequently. Follow this disease to get notified.
Specialists
View all specialists →Source: NPI Registry + PubMed · trial PI roles cross-referenced with ClinicalTrials.gov · ranked by match score (publications + PI activity + community signal)
No specialists are currently listed for OBSOLETE: Vascular malposition.
Treatment Centers
8 centersSource: NORD Rare Disease Centers + NIH Undiagnosed Diseases Network (UDN) · centers verified active within last 12 months
Children's Hospital Colorado Rare Disease Program ↗
Children's Hospital Colorado
📍 Aurora, CO
👤 Boston Children's Hospital Rare Disease Program
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDBoston Children's Hospital Rare Disease Program ↗
Boston Children's Hospital
📍 Boston, MA
👤 Boston Children's Hospital Rare Disease Program
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
🏨 Children'sAnn & Robert H. Lurie Children's Hospital Genetics ↗
Lurie Children's Hospital
📍 Chicago, IL
👤 Boston Children's Hospital Rare Disease Program
🏥 NORDCincinnati Children's Hospital Medical Center ↗
Cincinnati Children's
📍 Cincinnati, OH
👤 Boston Children's Hospital Rare Disease Program
🏨 Children'sNationwide Children's Hospital Rare Disease Center ↗
Nationwide Children's Hospital
📍 Columbus, OH
👤 Boston Children's Hospital Rare Disease Program
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
Travel Grants
No travel grants are currently matched to OBSOLETE: Vascular malposition.
Community
No community posts yet. Be the first to share your experience with OBSOLETE: Vascular malposition.
Start the conversation →Latest news about OBSOLETE: Vascular malposition
Source: PubMed + NIH RePORTER + openFDA + clinical-journal RSS · last 30 days · disease-tagged at ingest by AI extraction with human QC
No recent news articles for OBSOLETE: Vascular malposition.
Follow this condition to be notified when news becomes available.
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What is the exact name of my child's heart defect, now that 'vascular malposition' is an outdated term?,What surgery or procedures will my child need, and when?,What warning signs should prompt me to call 911 or go to the emergency room?,Will my child need lifelong heart medications or follow-up?,Are there any activity restrictions I should know about?,Should we have genetic testing to understand the cause and any risk for future pregnancies?,What does the long-term outlook look like for my child's specific condition?
Common questions about OBSOLETE: Vascular malposition
What is OBSOLETE: Vascular malposition?
Vascular malposition is a term that was previously used in medical records and older classification systems to describe a group of heart and blood vessel defects present at birth, where the major blood vessels leaving the heart are not in their correct positions. This entry is now considered 'obsolete' in current medical databases, meaning the term has been retired and replaced by more specific, modern diagnoses. The conditions it once described — such as transposition of the great arteries, double outlet right ventricle, or other conotruncal heart defects — involve the aorta and pulmonary art
At what age does OBSOLETE: Vascular malposition typically begin?
Typical onset of OBSOLETE: Vascular malposition is neonatal. Age of onset can vary across affected individuals.
Frequently asked questions about OBSOLETE: Vascular malposition
Auto-generated from canonical disease facts (Orphanet, OMIM, ClinicalTrials.gov, openFDA, NPPES). Not a substitute for clinical guidance.
What is OBSOLETE: Vascular malposition?
OBSOLETE: Vascular malposition is a rare disease catalogued in international rare-disease ontologies (Orphanet ORPHA:2452). It is typically inherited as variable. Age of onset is generally neonatal. For verified primary sources, see the UniteRare OBSOLETE: Vascular malposition page.
How is OBSOLETE: Vascular malposition inherited?
OBSOLETE: Vascular malposition follows variable inheritance. Genetic counseling is recommended for affected families to understand recurrence risk in offspring and the likelihood of unaffected siblings being carriers. Variants in the underlying gene(s) may be identified via clinical genetic testing.
Are there FDA-approved treatments for OBSOLETE: Vascular malposition?
Approved treatments for OBSOLETE: Vascular malposition are tracked from openFDA and DailyMed primary sources. Many rare diseases have no specific FDA-approved therapy; for those, supportive care and management of complications form the basis of clinical care. Orphan-drug-designation status is noted where applicable.
Are there clinical trials for OBSOLETE: Vascular malposition?
Active clinical trials for OBSOLETE: Vascular malposition are tracked daily from ClinicalTrials.gov. Trial availability changes frequently; check the UniteRare trial listings for the current count and recruitment status. Sponsors of rare-disease research often welcome inquiries even when a trial is not actively recruiting at a given moment.
How do I find a specialist for OBSOLETE: Vascular malposition?
Verified OBSOLETE: Vascular malposition specialists are identified through ClinicalTrials.gov principal-investigator records, peer-reviewed publication authorship (via PubMed), and the NPPES NPI registry. NORD-designated Centers of Excellence and NIH-affiliated rare-disease clinics are also tracked. UniteRare's specialist directory is updated continuously as new evidence becomes available.
See full OBSOLETE: Vascular malposition page for complete clinical details, sources, and verified-specialist listings.
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