What is OBSOLETE: Sino-auricular heart block?
Sino-auricular heart block, also known as sinoatrial (SA) block or sinus node exit block, is a condition that affects the heart's natural pacemaker. The sinoatrial node is a small cluster of cells in the upper right chamber of the heart that generates the electrical signals telling your heart when to beat. In SA block, these electrical signals are delayed or blocked before they can spread to the rest of the heart. This can cause the heart to skip beats or beat too slowly, a condition called bradycardia. People with SA block may experience dizziness, lightheadedness, fainting (syncope), fatigue, shortness of breath, or a feeling that the heart is skipping beats (palpitations). Some people have no symptoms at all and the condition is found during a routine heart check. SA block can range from mild to severe depending on the degree of the block. Note that this condition entry in Orphanet is marked as 'OBSOLETE,' meaning it may have been reclassified or merged with other cardiac conduction disorder categories. SA block can occur on its own or as part of a broader condition called sick sinus syndrome. Treatment depends on severity and may include monitoring, medication adjustments, or implantation of a permanent pacemaker for people with significant symptoms. Many cases are caused by aging, medications, or underlying heart disease rather than a single genetic cause, though rare familial forms have been described.
Key symptoms:
Dizziness or lightheadednessFainting or near-fainting episodesFatigue or unusual tirednessFeeling that the heart is skipping beats or flutteringShortness of breath, especially with activitySlow heart rateConfusion or difficulty concentratingExercise intoleranceChest discomfortPauses in heartbeat
- Inheritance
- Variable
- Can be inherited in different ways depending on the underlying gene
- Age of Onset
- Variable
- Can begin at different ages, from infancy through adulthood
FDA & Trial Timeline
8 eventsMicroPort CRM — NA
Abbott Medical Devices
Medtronic
University of Michigan — NA
Data is compiled from FDA regulatory filings and ClinicalTrials.gov, then processed through automated extraction; event classifications and dates may occasionally be misclassified. Verify against the linked FDA filing or trial record before clinical decisions. Updated periodically.
Treatments
Source: openFDA + DailyMed · NDA / BLA labels with structured indications · refreshed weekly
No FDA-approved treatments are currently listed for OBSOLETE: Sino-auricular heart block.
8 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.
View clinical trials →Source: ClinicalTrials.gov · synced daily · phases, status, and PI names normalized at ingest
Specialists
View all specialists →Source: NPI Registry + PubMed · trial PI roles cross-referenced with ClinicalTrials.gov · ranked by match score (publications + PI activity + community signal)
No specialists are currently listed for OBSOLETE: Sino-auricular heart block.
Treatment Centers
8 centersSource: NORD Rare Disease Centers + NIH Undiagnosed Diseases Network (UDN) · centers verified active within last 12 months
Children's Hospital Colorado Rare Disease Program ↗
Children's Hospital Colorado
📍 Aurora, CO
👤 Boston Children's Hospital Rare Disease Program
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDBoston Children's Hospital Rare Disease Program ↗
Boston Children's Hospital
📍 Boston, MA
👤 Boston Children's Hospital Rare Disease Program
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
🏨 Children'sAnn & Robert H. Lurie Children's Hospital Genetics ↗
Lurie Children's Hospital
📍 Chicago, IL
👤 Boston Children's Hospital Rare Disease Program
🏥 NORDCincinnati Children's Hospital Medical Center ↗
Cincinnati Children's
📍 Cincinnati, OH
👤 Boston Children's Hospital Rare Disease Program
🏨 Children'sNationwide Children's Hospital Rare Disease Center ↗
Nationwide Children's Hospital
📍 Columbus, OH
👤 Boston Children's Hospital Rare Disease Program
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
Travel Grants
No travel grants are currently matched to OBSOLETE: Sino-auricular heart block.
Community
No community posts yet. Be the first to share your experience with OBSOLETE: Sino-auricular heart block.
Start the conversation →Latest news about OBSOLETE: Sino-auricular heart block
Source: PubMed + NIH RePORTER + openFDA + clinical-journal RSS · last 30 days · disease-tagged at ingest by AI extraction with human QC
No recent news articles for OBSOLETE: Sino-auricular heart block.
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What degree of SA block do I have, and how severe is it?,Could any of my current medications be causing or worsening this condition?,Do I need a pacemaker, or can my condition be managed with monitoring alone?,Are there any activities or exercises I should avoid?,Should my family members be screened for heart rhythm problems?,How often will I need follow-up appointments and heart monitoring?,What symptoms should prompt me to go to the emergency room?
Common questions about OBSOLETE: Sino-auricular heart block
What is OBSOLETE: Sino-auricular heart block?
Sino-auricular heart block, also known as sinoatrial (SA) block or sinus node exit block, is a condition that affects the heart's natural pacemaker. The sinoatrial node is a small cluster of cells in the upper right chamber of the heart that generates the electrical signals telling your heart when to beat. In SA block, these electrical signals are delayed or blocked before they can spread to the rest of the heart. This can cause the heart to skip beats or beat too slowly, a condition called bradycardia. People with SA block may experience dizziness, lightheadedness, fainting (syncope), fatigu
Are there clinical trials for OBSOLETE: Sino-auricular heart block?
Yes — 8 recruiting clinical trials are currently listed for OBSOLETE: Sino-auricular heart block on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.
Frequently asked questions about OBSOLETE: Sino-auricular heart block
Auto-generated from canonical disease facts (Orphanet, OMIM, ClinicalTrials.gov, openFDA, NPPES). Not a substitute for clinical guidance.
What is OBSOLETE: Sino-auricular heart block?
OBSOLETE: Sino-auricular heart block is a rare disease catalogued in international rare-disease ontologies (Orphanet ORPHA:1260). It is typically inherited as variable. Age of onset is generally variable. For verified primary sources, see the UniteRare OBSOLETE: Sino-auricular heart block page.
How is OBSOLETE: Sino-auricular heart block inherited?
OBSOLETE: Sino-auricular heart block follows variable inheritance. Genetic counseling is recommended for affected families to understand recurrence risk in offspring and the likelihood of unaffected siblings being carriers. Variants in the underlying gene(s) may be identified via clinical genetic testing.
Are there FDA-approved treatments for OBSOLETE: Sino-auricular heart block?
Approved treatments for OBSOLETE: Sino-auricular heart block are tracked from openFDA and DailyMed primary sources. Many rare diseases have no specific FDA-approved therapy; for those, supportive care and management of complications form the basis of clinical care. Orphan-drug-designation status is noted where applicable.
Are there clinical trials recruiting for OBSOLETE: Sino-auricular heart block?
UniteRare currently lists 8 clinical trials relevant to OBSOLETE: Sino-auricular heart block sourced from ClinicalTrials.gov. Each trial entry includes recruitment status, eligibility criteria summary, principal-investigator information, and study locations. Patients should discuss eligibility with their healthcare provider before enrolling.
How do I find a specialist for OBSOLETE: Sino-auricular heart block?
Verified OBSOLETE: Sino-auricular heart block specialists are identified through ClinicalTrials.gov principal-investigator records, peer-reviewed publication authorship (via PubMed), and the NPPES NPI registry. NORD-designated Centers of Excellence and NIH-affiliated rare-disease clinics are also tracked. UniteRare's specialist directory is updated continuously as new evidence becomes available.
See full OBSOLETE: Sino-auricular heart block page for complete clinical details, sources, and verified-specialist listings.
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