Overview
Lymphoadenopathic mastocytosis with eosinophilia is a term that has been classified as obsolete in medical databases, meaning it is no longer used as a current diagnostic category. This condition was historically described as a form of systemic mastocytosis — a group of disorders in which abnormal mast cells (a type of immune cell) build up in various organs of the body, particularly the lymph nodes. In this specific form, patients experienced significant swelling of the lymph nodes (lymphadenopathy) along with an increase in eosinophils, which are another type of white blood cell involved in allergic and inflammatory responses. Symptoms that were associated with this condition included enlarged lymph nodes, skin flushing, itching, abdominal discomfort, and general signs of mast cell activation such as low blood pressure episodes and allergic-type reactions. The elevated eosinophils could also contribute to organ damage over time. Because this term is now obsolete, patients who might have previously received this diagnosis would today likely be classified under a more current category of systemic mastocytosis or a mast cell neoplasm according to updated World Health Organization (WHO) classification systems. Treatment approaches for related conditions typically involve medications that block the effects of mast cell chemicals (such as antihistamines), drugs that reduce mast cell numbers, and in some cases targeted therapies. Patients with a historical diagnosis should work with their doctors to ensure their condition is reclassified using current terminology so they can receive the most up-to-date care.
Key symptoms:
Swollen lymph nodesSkin flushing or rednessSevere itchingAbdominal pain or crampingDiarrheaLow blood pressure episodesFatigueBone painSkin rashes or hivesUnexplained weight lossAllergic-type reactionsElevated eosinophil counts on blood testsEnlarged liver or spleen
Sporadic
Usually appears on its own, not inherited from a parent
Adult
Begins in adulthood (age 18 or older)
Treatments
No FDA-approved treatments are currently listed for OBSOLETE: Lymphoadenopathic mastocytosis with eosinophilia.
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Specialists
View all specialists →No specialists are currently listed for OBSOLETE: Lymphoadenopathic mastocytosis with eosinophilia.
Treatment Centers
8 centersBaylor College of Medicine Rare Disease Center ↗
Baylor College of Medicine
📍 Houston, TX
🏥 NORDStanford Medicine Rare Disease Center ↗
Stanford Medicine
📍 Stanford, CA
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
🔬 UDNUCLA UDN Clinical Site ↗
UCLA Health
📍 Los Angeles, CA
🔬 UDNBaylor College of Medicine UDN Clinical Site ↗
Baylor College of Medicine
📍 Houston, TX
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDMayo Clinic Center for Individualized Medicine ↗
Mayo Clinic
📍 Rochester, MN
👤 Mayo Clinic Center for Individualized Medicine
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
Travel Grants
No travel grants are currently matched to OBSOLETE: Lymphoadenopathic mastocytosis with eosinophilia.
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Caregiver Resources
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Questions for your doctor
Bring these to your next appointment
- Q1.Since this diagnosis term is obsolete, what is my condition called under current classification systems?,What is the severity or subtype of my mastocytosis, and what does that mean for my outlook?,Should I be tested for the KIT gene mutation, and how would that affect my treatment?,What triggers should I avoid to prevent symptom flares or anaphylaxis?,Am I a candidate for targeted therapies like midostaurin or avapritinib?,How often do I need blood tests and bone marrow biopsies for monitoring?,Are there any clinical trials I should consider?
Common questions about OBSOLETE: Lymphoadenopathic mastocytosis with eosinophilia
What is OBSOLETE: Lymphoadenopathic mastocytosis with eosinophilia?
Lymphoadenopathic mastocytosis with eosinophilia is a term that has been classified as obsolete in medical databases, meaning it is no longer used as a current diagnostic category. This condition was historically described as a form of systemic mastocytosis — a group of disorders in which abnormal mast cells (a type of immune cell) build up in various organs of the body, particularly the lymph nodes. In this specific form, patients experienced significant swelling of the lymph nodes (lymphadenopathy) along with an increase in eosinophils, which are another type of white blood cell involved in
How is OBSOLETE: Lymphoadenopathic mastocytosis with eosinophilia inherited?
OBSOLETE: Lymphoadenopathic mastocytosis with eosinophilia follows a sporadic inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does OBSOLETE: Lymphoadenopathic mastocytosis with eosinophilia typically begin?
Typical onset of OBSOLETE: Lymphoadenopathic mastocytosis with eosinophilia is adult. Age of onset can vary across affected individuals.