What is OBSOLETE: Disorder with acute infantile liver failure?
This entry, listed under Orphanet code 464682, is classified as 'OBSOLETE: Disorder with acute infantile liver failure.' This means it was once used as a grouping term for conditions that cause sudden and severe liver failure in babies, but it has since been retired from active use in medical classification systems. The term was used to describe a group of rare genetic disorders where infants develop rapid, life-threatening liver failure, often within the first weeks or months of life. Symptoms typically included jaundice (yellowing of the skin and eyes), poor feeding, vomiting, bleeding problems, low blood sugar, and lethargy. Because this is now an obsolete classification, the specific conditions that were once grouped under this term have been reclassified into more precise diagnoses. These may include conditions such as neonatal hemochromatosis (also called gestational alloimmune liver disease), mitochondrial DNA depletion syndromes affecting the liver, and other inborn errors of metabolism that damage the liver in infancy. If your child has been given a diagnosis related to acute infantile liver failure, it is important to work with a specialist to identify the exact underlying genetic cause, as treatment and prognosis vary widely depending on the specific condition involved.
Key symptoms:
Yellowing of the skin and eyes (jaundice)Poor feeding or refusal to eatVomitingUnusual bleeding or bruisingLow blood sugarExtreme sleepiness or lethargySwollen belly due to enlarged liverDark urinePale or clay-colored stoolsFailure to gain weight or growIrritabilitySeizuresFluid buildup in the belly (ascites)
- Inheritance
- Variable
- Can be inherited in different ways depending on the underlying gene
- Age of Onset
- Infantile
- Begins in infancy, roughly 1 month to 2 years old
Treatments
Source: openFDA + DailyMed · NDA / BLA labels with structured indications · refreshed weekly
No FDA-approved treatments are currently listed for OBSOLETE: Disorder with acute infantile liver failure.
View clinical trials →Clinical Trials
View all trials with filters →Source: ClinicalTrials.gov · synced daily · phases, status, and PI names normalized at ingest
No actively recruiting trials found for OBSOLETE: Disorder with acute infantile liver failure at this time.
New trials open frequently. Follow this disease to get notified.
Specialists
View all specialists →Source: NPI Registry + PubMed · trial PI roles cross-referenced with ClinicalTrials.gov · ranked by match score (publications + PI activity + community signal)
No specialists are currently listed for OBSOLETE: Disorder with acute infantile liver failure.
Treatment Centers
8 centersSource: NORD Rare Disease Centers + NIH Undiagnosed Diseases Network (UDN) · centers verified active within last 12 months
Children's Hospital Colorado Rare Disease Program ↗
Children's Hospital Colorado
📍 Aurora, CO
👤 Boston Children's Hospital Rare Disease Program
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDBoston Children's Hospital Rare Disease Program ↗
Boston Children's Hospital
📍 Boston, MA
👤 Boston Children's Hospital Rare Disease Program
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
🏨 Children'sAnn & Robert H. Lurie Children's Hospital Genetics ↗
Lurie Children's Hospital
📍 Chicago, IL
👤 Boston Children's Hospital Rare Disease Program
🏥 NORDCincinnati Children's Hospital Medical Center ↗
Cincinnati Children's
📍 Cincinnati, OH
👤 Boston Children's Hospital Rare Disease Program
🏨 Children'sNationwide Children's Hospital Rare Disease Center ↗
Nationwide Children's Hospital
📍 Columbus, OH
👤 Boston Children's Hospital Rare Disease Program
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
Travel Grants
No travel grants are currently matched to OBSOLETE: Disorder with acute infantile liver failure.
Community
No community posts yet. Be the first to share your experience with OBSOLETE: Disorder with acute infantile liver failure.
Start the conversation →Latest news about OBSOLETE: Disorder with acute infantile liver failure
Source: PubMed + NIH RePORTER + openFDA + clinical-journal RSS · last 30 days · disease-tagged at ingest by AI extraction with human QC
No recent news articles for OBSOLETE: Disorder with acute infantile liver failure.
Follow this condition to be notified when news becomes available.
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What is the exact genetic or metabolic cause of my child's liver failure?,Is liver transplantation likely to be needed, and if so, when?,Are there any specific treatments or supplements that could help my child's condition?,What emergency signs should I watch for at home?,Will this condition affect other organs besides the liver?,What is the long-term outlook for my child?,Is genetic counseling recommended for our family regarding future pregnancies?
Common questions about OBSOLETE: Disorder with acute infantile liver failure
What is OBSOLETE: Disorder with acute infantile liver failure?
This entry, listed under Orphanet code 464682, is classified as 'OBSOLETE: Disorder with acute infantile liver failure.' This means it was once used as a grouping term for conditions that cause sudden and severe liver failure in babies, but it has since been retired from active use in medical classification systems. The term was used to describe a group of rare genetic disorders where infants develop rapid, life-threatening liver failure, often within the first weeks or months of life. Symptoms typically included jaundice (yellowing of the skin and eyes), poor feeding, vomiting, bleeding probl
At what age does OBSOLETE: Disorder with acute infantile liver failure typically begin?
Typical onset of OBSOLETE: Disorder with acute infantile liver failure is infantile. Age of onset can vary across affected individuals.
Frequently asked questions about OBSOLETE: Disorder with acute infantile liver failure
Auto-generated from canonical disease facts (Orphanet, OMIM, ClinicalTrials.gov, openFDA, NPPES). Not a substitute for clinical guidance.
What is OBSOLETE: Disorder with acute infantile liver failure?
OBSOLETE: Disorder with acute infantile liver failure is a rare disease catalogued in international rare-disease ontologies (Orphanet ORPHA:464682). It is typically inherited as variable. Age of onset is generally infantile. For verified primary sources, see the UniteRare OBSOLETE: Disorder with acute infantile liver failure page.
How is OBSOLETE: Disorder with acute infantile liver failure inherited?
OBSOLETE: Disorder with acute infantile liver failure follows variable inheritance. Genetic counseling is recommended for affected families to understand recurrence risk in offspring and the likelihood of unaffected siblings being carriers. Variants in the underlying gene(s) may be identified via clinical genetic testing.
Are there FDA-approved treatments for OBSOLETE: Disorder with acute infantile liver failure?
Approved treatments for OBSOLETE: Disorder with acute infantile liver failure are tracked from openFDA and DailyMed primary sources. Many rare diseases have no specific FDA-approved therapy; for those, supportive care and management of complications form the basis of clinical care. Orphan-drug-designation status is noted where applicable.
Are there clinical trials for OBSOLETE: Disorder with acute infantile liver failure?
Active clinical trials for OBSOLETE: Disorder with acute infantile liver failure are tracked daily from ClinicalTrials.gov. Trial availability changes frequently; check the UniteRare trial listings for the current count and recruitment status. Sponsors of rare-disease research often welcome inquiries even when a trial is not actively recruiting at a given moment.
How do I find a specialist for OBSOLETE: Disorder with acute infantile liver failure?
Verified OBSOLETE: Disorder with acute infantile liver failure specialists are identified through ClinicalTrials.gov principal-investigator records, peer-reviewed publication authorship (via PubMed), and the NPPES NPI registry. NORD-designated Centers of Excellence and NIH-affiliated rare-disease clinics are also tracked. UniteRare's specialist directory is updated continuously as new evidence becomes available.
See full OBSOLETE: Disorder with acute infantile liver failure page for complete clinical details, sources, and verified-specialist listings.
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