What is OBSOLETE: Collagenous colitis?
Collagenous colitis is a type of inflammatory bowel condition that affects the large intestine (colon). It belongs to a group of conditions called microscopic colitis, meaning the inflammation can only be seen under a microscope — the colon looks normal during a colonoscopy. In collagenous colitis, a thick band of collagen (a tough protein) builds up just beneath the inner lining of the colon, which interferes with how the colon absorbs water and nutrients. The most common symptom is chronic, watery diarrhea that can be very frequent — sometimes 10 or more times a day. This can lead to dehydration, fatigue, and significant disruption to daily life. Abdominal cramping, bloating, and unintentional weight loss are also common. The condition tends to affect middle-aged and older adults, particularly women. It is worth noting that Orphanet has marked this entry as 'obsolete,' meaning it has been reclassified or merged into a broader category (microscopic colitis) in current medical databases. However, the condition itself is still recognized and treated by gastroenterologists. Treatment options include anti-inflammatory medications, dietary changes, and in some cases drugs like budesonide, which is commonly used to reduce symptoms.
Key symptoms:
Chronic watery diarrhea (often many times per day)Abdominal cramping or painBloating and gasUnintentional weight lossFatigue and low energyNauseaFecal urgency (sudden strong need to use the bathroom)DehydrationNighttime diarrhea disrupting sleepReduced appetite
- Inheritance
- Multifactorial
- Caused by a mix of several genes and environmental factors
- Age of Onset
- Adult
- Begins in adulthood (age 18 or older)
Treatments
Source: openFDA + DailyMed · NDA / BLA labels with structured indications · refreshed weekly
No FDA-approved treatments are currently listed for OBSOLETE: Collagenous colitis.
View clinical trials →Clinical Trials
View all trials with filters →Source: ClinicalTrials.gov · synced daily · phases, status, and PI names normalized at ingest
No actively recruiting trials found for OBSOLETE: Collagenous colitis at this time.
New trials open frequently. Follow this disease to get notified.
Specialists
View all specialists →Source: NPI Registry + PubMed · trial PI roles cross-referenced with ClinicalTrials.gov · ranked by match score (publications + PI activity + community signal)
No specialists are currently listed for OBSOLETE: Collagenous colitis.
Treatment Centers
8 centersSource: NORD Rare Disease Centers + NIH Undiagnosed Diseases Network (UDN) · centers verified active within last 12 months
Children's Hospital Colorado Rare Disease Program ↗
Children's Hospital Colorado
📍 Aurora, CO
👤 Boston Children's Hospital Rare Disease Program
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDBoston Children's Hospital Rare Disease Program ↗
Boston Children's Hospital
📍 Boston, MA
👤 Boston Children's Hospital Rare Disease Program
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
🏨 Children'sAnn & Robert H. Lurie Children's Hospital Genetics ↗
Lurie Children's Hospital
📍 Chicago, IL
👤 Boston Children's Hospital Rare Disease Program
🏥 NORDCincinnati Children's Hospital Medical Center ↗
Cincinnati Children's
📍 Cincinnati, OH
👤 Boston Children's Hospital Rare Disease Program
🏨 Children'sNationwide Children's Hospital Rare Disease Center ↗
Nationwide Children's Hospital
📍 Columbus, OH
👤 Boston Children's Hospital Rare Disease Program
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
Travel Grants
No travel grants are currently matched to OBSOLETE: Collagenous colitis.
Community
No community posts yet. Be the first to share your experience with OBSOLETE: Collagenous colitis.
Start the conversation →Latest news about OBSOLETE: Collagenous colitis
Source: PubMed + NIH RePORTER + openFDA + clinical-journal RSS · last 30 days · disease-tagged at ingest by AI extraction with human QC
No recent news articles for OBSOLETE: Collagenous colitis.
Follow this condition to be notified when news becomes available.
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What medications or foods might be triggering my symptoms, and should I stop any current medications?,Is budesonide the right treatment for me, and what are the risks of long-term use?,How will we know if the treatment is working, and what happens if it stops working?,Are there dietary changes that could help reduce my symptoms?,What are the chances of my symptoms going into remission on their own?,Do I need regular colonoscopies or follow-up biopsies?,Are there any clinical trials or newer treatments I should know about?
Common questions about OBSOLETE: Collagenous colitis
What is OBSOLETE: Collagenous colitis?
Collagenous colitis is a type of inflammatory bowel condition that affects the large intestine (colon). It belongs to a group of conditions called microscopic colitis, meaning the inflammation can only be seen under a microscope — the colon looks normal during a colonoscopy. In collagenous colitis, a thick band of collagen (a tough protein) builds up just beneath the inner lining of the colon, which interferes with how the colon absorbs water and nutrients. The most common symptom is chronic, watery diarrhea that can be very frequent — sometimes 10 or more times a day. This can lead to dehydr
How is OBSOLETE: Collagenous colitis inherited?
OBSOLETE: Collagenous colitis follows a multifactorial inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does OBSOLETE: Collagenous colitis typically begin?
Typical onset of OBSOLETE: Collagenous colitis is adult. Age of onset can vary across affected individuals.
Frequently asked questions about OBSOLETE: Collagenous colitis
Auto-generated from canonical disease facts (Orphanet, OMIM, ClinicalTrials.gov, openFDA, NPPES). Not a substitute for clinical guidance.
What is OBSOLETE: Collagenous colitis?
OBSOLETE: Collagenous colitis is a rare disease catalogued in international rare-disease ontologies (Orphanet ORPHA:36205). It is typically inherited as multifactorial. Age of onset is generally adult. For verified primary sources, see the UniteRare OBSOLETE: Collagenous colitis page.
How is OBSOLETE: Collagenous colitis inherited?
OBSOLETE: Collagenous colitis follows multifactorial inheritance. Genetic counseling is recommended for affected families to understand recurrence risk in offspring and the likelihood of unaffected siblings being carriers. Variants in the underlying gene(s) may be identified via clinical genetic testing.
Are there FDA-approved treatments for OBSOLETE: Collagenous colitis?
Approved treatments for OBSOLETE: Collagenous colitis are tracked from openFDA and DailyMed primary sources. Many rare diseases have no specific FDA-approved therapy; for those, supportive care and management of complications form the basis of clinical care. Orphan-drug-designation status is noted where applicable.
Are there clinical trials for OBSOLETE: Collagenous colitis?
Active clinical trials for OBSOLETE: Collagenous colitis are tracked daily from ClinicalTrials.gov. Trial availability changes frequently; check the UniteRare trial listings for the current count and recruitment status. Sponsors of rare-disease research often welcome inquiries even when a trial is not actively recruiting at a given moment.
How do I find a specialist for OBSOLETE: Collagenous colitis?
Verified OBSOLETE: Collagenous colitis specialists are identified through ClinicalTrials.gov principal-investigator records, peer-reviewed publication authorship (via PubMed), and the NPPES NPI registry. NORD-designated Centers of Excellence and NIH-affiliated rare-disease clinics are also tracked. UniteRare's specialist directory is updated continuously as new evidence becomes available.
See full OBSOLETE: Collagenous colitis page for complete clinical details, sources, and verified-specialist listings.
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