What is NON RARE IN EUROPE: Primary adult open-angle glaucoma?
Primary open-angle glaucoma (POAG) is the most common form of glaucoma in adults. It is a condition where the optic nerve at the back of the eye becomes gradually damaged, usually because the pressure inside the eye (called intraocular pressure) is too high. The drainage system of the eye slowly becomes less efficient over time, causing fluid to build up and pressure to increase. However, some people develop POAG even with normal eye pressure, which is called normal-tension glaucoma. POAG is often called the 'silent thief of sight' because it usually causes no pain and no noticeable symptoms in its early stages. Vision loss begins with peripheral (side) vision and slowly progresses inward. By the time a person notices vision changes, significant and irreversible damage may have already occurred. This is why regular eye exams are so important, especially after age 40. Treatment focuses on lowering eye pressure to slow or stop further nerve damage. This can be done with prescription eye drops, laser treatments, or surgery. While there is no cure and lost vision cannot be restored, early detection and consistent treatment can preserve remaining vision for most people. Several classes of medications are available, including prostaglandin analogs like latanoprost, beta-blockers like timolol, and newer agents like netarsudil. Laser trabeculoplasty and surgical options such as trabeculectomy or minimally invasive glaucoma surgery (MIGS) are also widely used.
Also known as:
Key symptoms:
Gradual loss of side (peripheral) visionTunnel vision in advanced stagesDifficulty seeing in dim lightingTrouble adjusting to dark roomsBlurred visionSeeing halos around lightsDifficulty with contrast sensitivityFrequent changes in eyeglass prescriptionEye pressure that is higher than normalLoss of central vision in very late stagesNo pain or symptoms in early stages
- Inheritance
- Multifactorial
- Caused by a mix of several genes and environmental factors
- Age of Onset
- Adult
- Begins in adulthood (age 18 or older)
FDA & Trial Timeline
10 eventsSakarya Yenikent State Hospital — NA
Qlaris Bio, Inc. — PHASE2, PHASE3
Hospices Civils de Lyon
Peking Union Medical College Hospital
IVIEW Therapeutics Inc. — PHASE1, PHASE2
Università degli Studi 'G. d'Annunzio' Chieti e Pescara — NA
Alcon Research — PHASE3
Qlaris Bio, Inc. — PHASE2
Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts — NA
Okuvision GmbH — NA
Data is compiled from FDA regulatory filings and ClinicalTrials.gov, then processed through automated extraction; event classifications and dates may occasionally be misclassified. Verify against the linked FDA filing or trial record before clinical decisions. Updated periodically.
Treatments
Source: openFDA + DailyMed · NDA / BLA labels with structured indications · refreshed weekly
No FDA-approved treatments are currently listed for NON RARE IN EUROPE: Primary adult open-angle glaucoma.
19 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.
View clinical trials →Source: ClinicalTrials.gov · synced daily · phases, status, and PI names normalized at ingest
Specialists
View all specialists →Source: NPI Registry + PubMed · trial PI roles cross-referenced with ClinicalTrials.gov · ranked by match score (publications + PI activity + community signal)
No specialists are currently listed for NON RARE IN EUROPE: Primary adult open-angle glaucoma.
Treatment Centers
8 centersSource: NORD Rare Disease Centers + NIH Undiagnosed Diseases Network (UDN) · centers verified active within last 12 months
Children's Hospital Colorado Rare Disease Program ↗
Children's Hospital Colorado
📍 Aurora, CO
👤 Boston Children's Hospital Rare Disease Program
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDBoston Children's Hospital Rare Disease Program ↗
Boston Children's Hospital
📍 Boston, MA
👤 Boston Children's Hospital Rare Disease Program
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
🏨 Children'sAnn & Robert H. Lurie Children's Hospital Genetics ↗
Lurie Children's Hospital
📍 Chicago, IL
👤 Boston Children's Hospital Rare Disease Program
🏥 NORDCincinnati Children's Hospital Medical Center ↗
Cincinnati Children's
📍 Cincinnati, OH
👤 Boston Children's Hospital Rare Disease Program
🏨 Children'sNationwide Children's Hospital Rare Disease Center ↗
Nationwide Children's Hospital
📍 Columbus, OH
👤 Boston Children's Hospital Rare Disease Program
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
Travel Grants
No travel grants are currently matched to NON RARE IN EUROPE: Primary adult open-angle glaucoma.
Community
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Start the conversation →Latest news about NON RARE IN EUROPE: Primary adult open-angle glaucoma
Source: PubMed + NIH RePORTER + openFDA + clinical-journal RSS · last 30 days · disease-tagged at ingest by AI extraction with human QC
No recent news articles for NON RARE IN EUROPE: Primary adult open-angle glaucoma.
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.How advanced is my glaucoma, and how much vision have I already lost?,What is my target eye pressure, and how will we know if treatment is working?,What are the side effects of the eye drops you are prescribing?,Should my family members be screened for glaucoma?,How often do I need to come in for check-ups?,If eye drops don't work well enough, what are my next treatment options?,Are there any lifestyle changes I can make to help protect my vision?
Common questions about NON RARE IN EUROPE: Primary adult open-angle glaucoma
What is NON RARE IN EUROPE: Primary adult open-angle glaucoma?
Primary open-angle glaucoma (POAG) is the most common form of glaucoma in adults. It is a condition where the optic nerve at the back of the eye becomes gradually damaged, usually because the pressure inside the eye (called intraocular pressure) is too high. The drainage system of the eye slowly becomes less efficient over time, causing fluid to build up and pressure to increase. However, some people develop POAG even with normal eye pressure, which is called normal-tension glaucoma. POAG is often called the 'silent thief of sight' because it usually causes no pain and no noticeable symptoms
How is NON RARE IN EUROPE: Primary adult open-angle glaucoma inherited?
NON RARE IN EUROPE: Primary adult open-angle glaucoma follows a multifactorial inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does NON RARE IN EUROPE: Primary adult open-angle glaucoma typically begin?
Typical onset of NON RARE IN EUROPE: Primary adult open-angle glaucoma is adult. Age of onset can vary across affected individuals.
Are there clinical trials for NON RARE IN EUROPE: Primary adult open-angle glaucoma?
Yes — 19 recruiting clinical trials are currently listed for NON RARE IN EUROPE: Primary adult open-angle glaucoma on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.
Frequently asked questions about NON RARE IN EUROPE: Primary adult open-angle glaucoma
Auto-generated from canonical disease facts (Orphanet, OMIM, ClinicalTrials.gov, openFDA, NPPES). Not a substitute for clinical guidance.
What is NON RARE IN EUROPE: Primary adult open-angle glaucoma?
NON RARE IN EUROPE: Primary adult open-angle glaucoma is a rare disease catalogued in international rare-disease ontologies (Orphanet ORPHA:353225). It is typically inherited as multifactorial. Age of onset is generally adult. For verified primary sources, see the UniteRare NON RARE IN EUROPE: Primary adult open-angle glaucoma page.
How is NON RARE IN EUROPE: Primary adult open-angle glaucoma inherited?
NON RARE IN EUROPE: Primary adult open-angle glaucoma follows multifactorial inheritance. Genetic counseling is recommended for affected families to understand recurrence risk in offspring and the likelihood of unaffected siblings being carriers. Variants in the underlying gene(s) may be identified via clinical genetic testing.
Are there FDA-approved treatments for NON RARE IN EUROPE: Primary adult open-angle glaucoma?
Approved treatments for NON RARE IN EUROPE: Primary adult open-angle glaucoma are tracked from openFDA and DailyMed primary sources. Many rare diseases have no specific FDA-approved therapy; for those, supportive care and management of complications form the basis of clinical care. Orphan-drug-designation status is noted where applicable.
Are there clinical trials recruiting for NON RARE IN EUROPE: Primary adult open-angle glaucoma?
UniteRare currently lists 19 clinical trials relevant to NON RARE IN EUROPE: Primary adult open-angle glaucoma sourced from ClinicalTrials.gov. Each trial entry includes recruitment status, eligibility criteria summary, principal-investigator information, and study locations. Patients should discuss eligibility with their healthcare provider before enrolling.
How do I find a specialist for NON RARE IN EUROPE: Primary adult open-angle glaucoma?
Verified NON RARE IN EUROPE: Primary adult open-angle glaucoma specialists are identified through ClinicalTrials.gov principal-investigator records, peer-reviewed publication authorship (via PubMed), and the NPPES NPI registry. NORD-designated Centers of Excellence and NIH-affiliated rare-disease clinics are also tracked. UniteRare's specialist directory is updated continuously as new evidence becomes available.
See full NON RARE IN EUROPE: Primary adult open-angle glaucoma page for complete clinical details, sources, and verified-specialist listings.
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