What is NON RARE IN EUROPE: Non-alcoholic fatty liver disease?
Non-alcoholic fatty liver disease (NAFLD) is a condition where too much fat builds up in the liver in people who drink little or no alcohol. It is one of the most common liver conditions in the world. NAFLD covers a range of problems, from simple fat buildup (called steatosis or 'fatty liver') to a more serious form called non-alcoholic steatohepatitis (NASH), where the liver becomes inflamed and damaged. Over time, NASH can lead to scarring of the liver (fibrosis or cirrhosis) and, in some cases, liver failure or liver cancer. Many people with NAFLD have no symptoms at all, especially in the early stages. When symptoms do appear, they can include tiredness, mild discomfort or pain in the upper right side of the belly, and feeling generally unwell. NAFLD is closely linked to obesity, type 2 diabetes, high blood pressure, and high cholesterol — a group of conditions sometimes called metabolic syndrome. Treatment mainly focuses on lifestyle changes such as losing weight, eating a healthier diet, exercising regularly, and managing related conditions like diabetes and high cholesterol. There are currently very few approved medications specifically for NAFLD, though several are being studied. In advanced cases, a liver transplant may be needed. Early detection and lifestyle changes can significantly slow or even reverse the disease.
Also known as:
Key symptoms:
Fatigue or low energyDull ache or discomfort in the upper right side of the abdomenUnexplained weight gain, especially around the bellyFeeling generally unwellEnlarged liver (found on scan or exam)Yellowing of the skin or eyes (jaundice) — in advanced diseaseSwollen belly due to fluid buildup (ascites) — in advanced diseaseEasy bruising or bleeding — in advanced diseaseSwollen legs or ankles — in advanced diseaseConfusion or difficulty thinking clearly (hepatic encephalopathy) — in severe cases
- Inheritance
- Multifactorial
- Caused by a mix of several genes and environmental factors
- Age of Onset
- Variable
- Can begin at different ages, from infancy through adulthood
FDA & Trial Timeline
10 eventsGlaxoSmithKline — PHASE1
Institute of Liver and Biliary Sciences, India — NA
The Affiliated Hospital of Hangzhou Normal University — NA
Dong Hui — PHASE2
Steno Diabetes Center Copenhagen — NA
Rigshospitalet, Denmark — NA
Zhujiang Hospital — PHASE4
Charite University, Berlin, Germany — NA
Western University, Canada — NA
Data is compiled from FDA regulatory filings and ClinicalTrials.gov, then processed through automated extraction; event classifications and dates may occasionally be misclassified. Verify against the linked FDA filing or trial record before clinical decisions. Updated periodically.
Treatments
Source: openFDA + DailyMed · NDA / BLA labels with structured indications · refreshed weekly
No FDA-approved treatments are currently listed for NON RARE IN EUROPE: Non-alcoholic fatty liver disease.
15 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.
View clinical trials →Source: ClinicalTrials.gov · synced daily · phases, status, and PI names normalized at ingest
Specialists
View all specialists →Source: NPI Registry + PubMed · trial PI roles cross-referenced with ClinicalTrials.gov · ranked by match score (publications + PI activity + community signal)
No specialists are currently listed for NON RARE IN EUROPE: Non-alcoholic fatty liver disease.
Treatment Centers
8 centersSource: NORD Rare Disease Centers + NIH Undiagnosed Diseases Network (UDN) · centers verified active within last 12 months
Children's Hospital Colorado Rare Disease Program ↗
Children's Hospital Colorado
📍 Aurora, CO
👤 Boston Children's Hospital Rare Disease Program
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDBoston Children's Hospital Rare Disease Program ↗
Boston Children's Hospital
📍 Boston, MA
👤 Boston Children's Hospital Rare Disease Program
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
🏨 Children'sAnn & Robert H. Lurie Children's Hospital Genetics ↗
Lurie Children's Hospital
📍 Chicago, IL
👤 Boston Children's Hospital Rare Disease Program
🏥 NORDCincinnati Children's Hospital Medical Center ↗
Cincinnati Children's
📍 Cincinnati, OH
👤 Boston Children's Hospital Rare Disease Program
🏨 Children'sNationwide Children's Hospital Rare Disease Center ↗
Nationwide Children's Hospital
📍 Columbus, OH
👤 Boston Children's Hospital Rare Disease Program
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
Travel Grants
No travel grants are currently matched to NON RARE IN EUROPE: Non-alcoholic fatty liver disease.
Community
No community posts yet. Be the first to share your experience with NON RARE IN EUROPE: Non-alcoholic fatty liver disease.
Start the conversation →Latest news about NON RARE IN EUROPE: Non-alcoholic fatty liver disease
Source: PubMed + NIH RePORTER + openFDA + clinical-journal RSS · last 30 days · disease-tagged at ingest by AI extraction with human QC
No recent news articles for NON RARE IN EUROPE: Non-alcoholic fatty liver disease.
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.What stage of NAFLD do I have, and how much liver damage is there?,Do I need a liver biopsy, or can my condition be monitored with scans and blood tests?,How much weight do I need to lose to improve my liver health, and what support is available to help me?,Should I be tested or treated for related conditions like diabetes, high cholesterol, or high blood pressure?,Are there any medications I should avoid because of my liver condition?,Am I a candidate for any new medications like resmetirom, or are there clinical trials I could join?,How often do I need follow-up tests, and what signs should prompt me to seek urgent care?
Common questions about NON RARE IN EUROPE: Non-alcoholic fatty liver disease
What is NON RARE IN EUROPE: Non-alcoholic fatty liver disease?
Non-alcoholic fatty liver disease (NAFLD) is a condition where too much fat builds up in the liver in people who drink little or no alcohol. It is one of the most common liver conditions in the world. NAFLD covers a range of problems, from simple fat buildup (called steatosis or 'fatty liver') to a more serious form called non-alcoholic steatohepatitis (NASH), where the liver becomes inflamed and damaged. Over time, NASH can lead to scarring of the liver (fibrosis or cirrhosis) and, in some cases, liver failure or liver cancer. Many people with NAFLD have no symptoms at all, especially in the
How is NON RARE IN EUROPE: Non-alcoholic fatty liver disease inherited?
NON RARE IN EUROPE: Non-alcoholic fatty liver disease follows a multifactorial inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
Are there clinical trials for NON RARE IN EUROPE: Non-alcoholic fatty liver disease?
Yes — 15 recruiting clinical trials are currently listed for NON RARE IN EUROPE: Non-alcoholic fatty liver disease on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.
Frequently asked questions about NON RARE IN EUROPE: Non-alcoholic fatty liver disease
Auto-generated from canonical disease facts (Orphanet, OMIM, ClinicalTrials.gov, openFDA, NPPES). Not a substitute for clinical guidance.
What is NON RARE IN EUROPE: Non-alcoholic fatty liver disease?
NON RARE IN EUROPE: Non-alcoholic fatty liver disease is a rare disease catalogued in international rare-disease ontologies (Orphanet ORPHA:33271). It is typically inherited as multifactorial. Age of onset is generally variable. For verified primary sources, see the UniteRare NON RARE IN EUROPE: Non-alcoholic fatty liver disease page.
How is NON RARE IN EUROPE: Non-alcoholic fatty liver disease inherited?
NON RARE IN EUROPE: Non-alcoholic fatty liver disease follows multifactorial inheritance. Genetic counseling is recommended for affected families to understand recurrence risk in offspring and the likelihood of unaffected siblings being carriers. Variants in the underlying gene(s) may be identified via clinical genetic testing.
Are there FDA-approved treatments for NON RARE IN EUROPE: Non-alcoholic fatty liver disease?
Approved treatments for NON RARE IN EUROPE: Non-alcoholic fatty liver disease are tracked from openFDA and DailyMed primary sources. Many rare diseases have no specific FDA-approved therapy; for those, supportive care and management of complications form the basis of clinical care. Orphan-drug-designation status is noted where applicable.
Are there clinical trials recruiting for NON RARE IN EUROPE: Non-alcoholic fatty liver disease?
UniteRare currently lists 15 clinical trials relevant to NON RARE IN EUROPE: Non-alcoholic fatty liver disease sourced from ClinicalTrials.gov. Each trial entry includes recruitment status, eligibility criteria summary, principal-investigator information, and study locations. Patients should discuss eligibility with their healthcare provider before enrolling.
How do I find a specialist for NON RARE IN EUROPE: Non-alcoholic fatty liver disease?
Verified NON RARE IN EUROPE: Non-alcoholic fatty liver disease specialists are identified through ClinicalTrials.gov principal-investigator records, peer-reviewed publication authorship (via PubMed), and the NPPES NPI registry. NORD-designated Centers of Excellence and NIH-affiliated rare-disease clinics are also tracked. UniteRare's specialist directory is updated continuously as new evidence becomes available.
See full NON RARE IN EUROPE: Non-alcoholic fatty liver disease page for complete clinical details, sources, and verified-specialist listings.
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