What is NON RARE IN EUROPE: Metabolic syndrome?
Metabolic syndrome is a common condition where several health problems occur together, raising your risk of heart disease, stroke, and type 2 diabetes. It is not considered a rare disease in Europe, but it is tracked in medical databases because of its significant health impact. To be diagnosed with metabolic syndrome, you typically need to have at least three of the following five conditions at the same time: a large waistline (excess belly fat), high blood pressure, high blood sugar levels, high triglycerides (a type of fat in the blood), and low levels of HDL cholesterol (the "good" cholesterol). Each of these problems is harmful on its own, but when they cluster together, the risks multiply significantly. Metabolic syndrome develops gradually over time and is strongly linked to being overweight, physical inactivity, and insulin resistance — a condition where your body does not use insulin properly. Genetics also play a role, as the tendency to develop these metabolic problems can run in families. The condition is sometimes called Syndrome X, insulin resistance syndrome, or dysmetabolic syndrome. The good news is that metabolic syndrome is largely manageable and even reversible with lifestyle changes. Losing weight, eating a heart-healthy diet, exercising regularly, and quitting smoking can dramatically improve all the components of the syndrome. When lifestyle changes are not enough, doctors may prescribe medications to control blood pressure, blood sugar, and cholesterol levels individually. Early detection and consistent management are key to preventing serious complications like heart attacks and diabetes.
Key symptoms:
Large waistline or excess belly fatHigh blood pressureHigh blood sugar or prediabetesHigh triglyceride levels in the bloodLow HDL (good) cholesterol levelsFatigue and low energyIncreased thirst and frequent urinationBlurred visionSkin tagsDark patches of skin on the neck or armpits (acanthosis nigricans)Difficulty losing weightFeeling hungry often
- Inheritance
- Multifactorial
- Caused by a mix of several genes and environmental factors
- Age of Onset
- Adult
- Begins in adulthood (age 18 or older)
FDA & Trial Timeline
10 eventsUniversity of Zadar — NA
Pomeranian Medical University Szczecin
Tarumanagara University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) — PHASE2
Abant Izzet Baysal University
Center of New Medical Technologies
National Cattlemen's Beef Association, a contractor to the Beef Checkoff — NA
Fondazione Policlinico Universitario Agostino Gemelli IRCCS — NA
National University Health System, Singapore — NA
Data is compiled from FDA regulatory filings and ClinicalTrials.gov, then processed through automated extraction; event classifications and dates may occasionally be misclassified. Verify against the linked FDA filing or trial record before clinical decisions. Updated periodically.
Treatments
Source: openFDA + DailyMed · NDA / BLA labels with structured indications · refreshed weekly
No FDA-approved treatments are currently listed for NON RARE IN EUROPE: Metabolic syndrome.
20 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.
View clinical trials →Source: ClinicalTrials.gov · synced daily · phases, status, and PI names normalized at ingest
Specialists
View all specialists →Source: NPI Registry + PubMed · trial PI roles cross-referenced with ClinicalTrials.gov · ranked by match score (publications + PI activity + community signal)
No specialists are currently listed for NON RARE IN EUROPE: Metabolic syndrome.
Treatment Centers
8 centersSource: NORD Rare Disease Centers + NIH Undiagnosed Diseases Network (UDN) · centers verified active within last 12 months
Children's Hospital Colorado Rare Disease Program ↗
Children's Hospital Colorado
📍 Aurora, CO
👤 Boston Children's Hospital Rare Disease Program
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDBoston Children's Hospital Rare Disease Program ↗
Boston Children's Hospital
📍 Boston, MA
👤 Boston Children's Hospital Rare Disease Program
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
🏨 Children'sAnn & Robert H. Lurie Children's Hospital Genetics ↗
Lurie Children's Hospital
📍 Chicago, IL
👤 Boston Children's Hospital Rare Disease Program
🏥 NORDCincinnati Children's Hospital Medical Center ↗
Cincinnati Children's
📍 Cincinnati, OH
👤 Boston Children's Hospital Rare Disease Program
🏨 Children'sNationwide Children's Hospital Rare Disease Center ↗
Nationwide Children's Hospital
📍 Columbus, OH
👤 Boston Children's Hospital Rare Disease Program
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
Travel Grants
No travel grants are currently matched to NON RARE IN EUROPE: Metabolic syndrome.
Community
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Start the conversation →Latest news about NON RARE IN EUROPE: Metabolic syndrome
Source: PubMed + NIH RePORTER + openFDA + clinical-journal RSS · last 30 days · disease-tagged at ingest by AI extraction with human QC
No recent news articles for NON RARE IN EUROPE: Metabolic syndrome.
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Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.Which specific components of metabolic syndrome do I have, and which are the most concerning for me?,What is my current risk level for developing heart disease or type 2 diabetes?,What specific dietary changes would benefit me the most?,How much weight loss would I need to achieve to significantly improve my condition?,Do I need medications right now, or can I try lifestyle changes first?,How often should I have my blood pressure, blood sugar, and cholesterol levels checked?,Should my family members be screened for metabolic syndrome as well?
Common questions about NON RARE IN EUROPE: Metabolic syndrome
What is NON RARE IN EUROPE: Metabolic syndrome?
Metabolic syndrome is a common condition where several health problems occur together, raising your risk of heart disease, stroke, and type 2 diabetes. It is not considered a rare disease in Europe, but it is tracked in medical databases because of its significant health impact. To be diagnosed with metabolic syndrome, you typically need to have at least three of the following five conditions at the same time: a large waistline (excess belly fat), high blood pressure, high blood sugar levels, high triglycerides (a type of fat in the blood), and low levels of HDL cholesterol (the "good" cholest
How is NON RARE IN EUROPE: Metabolic syndrome inherited?
NON RARE IN EUROPE: Metabolic syndrome follows a multifactorial inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does NON RARE IN EUROPE: Metabolic syndrome typically begin?
Typical onset of NON RARE IN EUROPE: Metabolic syndrome is adult. Age of onset can vary across affected individuals.
Are there clinical trials for NON RARE IN EUROPE: Metabolic syndrome?
Yes — 20 recruiting clinical trials are currently listed for NON RARE IN EUROPE: Metabolic syndrome on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.
Frequently asked questions about NON RARE IN EUROPE: Metabolic syndrome
Auto-generated from canonical disease facts (Orphanet, OMIM, ClinicalTrials.gov, openFDA, NPPES). Not a substitute for clinical guidance.
What is NON RARE IN EUROPE: Metabolic syndrome?
NON RARE IN EUROPE: Metabolic syndrome is a rare disease catalogued in international rare-disease ontologies (Orphanet ORPHA:411969). It is typically inherited as multifactorial. Age of onset is generally adult. For verified primary sources, see the UniteRare NON RARE IN EUROPE: Metabolic syndrome page.
How is NON RARE IN EUROPE: Metabolic syndrome inherited?
NON RARE IN EUROPE: Metabolic syndrome follows multifactorial inheritance. Genetic counseling is recommended for affected families to understand recurrence risk in offspring and the likelihood of unaffected siblings being carriers. Variants in the underlying gene(s) may be identified via clinical genetic testing.
Are there FDA-approved treatments for NON RARE IN EUROPE: Metabolic syndrome?
Approved treatments for NON RARE IN EUROPE: Metabolic syndrome are tracked from openFDA and DailyMed primary sources. Many rare diseases have no specific FDA-approved therapy; for those, supportive care and management of complications form the basis of clinical care. Orphan-drug-designation status is noted where applicable.
Are there clinical trials recruiting for NON RARE IN EUROPE: Metabolic syndrome?
UniteRare currently lists 20 clinical trials relevant to NON RARE IN EUROPE: Metabolic syndrome sourced from ClinicalTrials.gov. Each trial entry includes recruitment status, eligibility criteria summary, principal-investigator information, and study locations. Patients should discuss eligibility with their healthcare provider before enrolling.
How do I find a specialist for NON RARE IN EUROPE: Metabolic syndrome?
Verified NON RARE IN EUROPE: Metabolic syndrome specialists are identified through ClinicalTrials.gov principal-investigator records, peer-reviewed publication authorship (via PubMed), and the NPPES NPI registry. NORD-designated Centers of Excellence and NIH-affiliated rare-disease clinics are also tracked. UniteRare's specialist directory is updated continuously as new evidence becomes available.
See full NON RARE IN EUROPE: Metabolic syndrome page for complete clinical details, sources, and verified-specialist listings.
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