What is NON RARE IN EUROPE: Juvenile idiopathic scoliosis?
Juvenile idiopathic scoliosis is a sideways curvature of the spine that develops in children between the ages of 4 and 10 years old. The word 'idiopathic' means the cause is unknown — there is no clear underlying disease or condition that explains why the spine curves. This condition is sometimes simply called juvenile scoliosis. The spine may curve into a C-shape or S-shape, and the curve can worsen as the child grows, especially during growth spurts. Children with juvenile idiopathic scoliosis may notice that their shoulders or hips appear uneven, one shoulder blade sticks out more than the other, or their waistline looks uneven. In mild cases, there may be no pain or other symptoms. However, if the curve becomes severe, it can affect how the lungs and heart work because the rib cage may become distorted. Treatment depends on how severe the curve is and how much growing the child still has to do. Mild curves are monitored with regular check-ups and X-rays. Moderate curves may be treated with bracing to prevent the curve from getting worse during growth. In more severe cases, surgery may be needed to straighten and stabilize the spine. Physical therapy and exercise can also help with posture and strength. Early detection and monitoring are very important because children in this age group still have significant growth ahead, which means curves can progress quickly.
Key symptoms:
Sideways curvature of the spineUneven shoulders — one higher than the otherOne shoulder blade sticking out more than the otherUneven waistline or hipsLeaning to one side when standingRib hump visible when bending forwardClothes fitting unevenlyBack pain in some casesFatigue with prolonged sitting or standingReduced flexibility of the spineBreathing difficulties in severe casesVisible asymmetry of the trunk or torso
- Inheritance
- Multifactorial
- Caused by a mix of several genes and environmental factors
- Age of Onset
- Juvenile
- Begins in the teen years
FDA & Trial Timeline
10 eventsMarmara University — NA
Cairo University — NA
University of Malaya — NA
Armed Forces Hospitals, Southern Region, Saudi Arabia — NA
Jinan University Guangzhou — NA
Nigde Omer Halisdemir University
Hacettepe University
Gözde Yagci (Gür) — NA
Istituto Scientifico Italiano Colonna Vertebrale — NA
Data is compiled from FDA regulatory filings and ClinicalTrials.gov, then processed through automated extraction; event classifications and dates may occasionally be misclassified. Verify against the linked FDA filing or trial record before clinical decisions. Updated periodically.
Treatments
Source: openFDA + DailyMed · NDA / BLA labels with structured indications · refreshed weekly
No FDA-approved treatments are currently listed for NON RARE IN EUROPE: Juvenile idiopathic scoliosis.
20 clinical trialsare actively recruiting — trials can provide access to cutting-edge therapies.
View clinical trials →Source: ClinicalTrials.gov · synced daily · phases, status, and PI names normalized at ingest
Specialists
View all specialists →Source: NPI Registry + PubMed · trial PI roles cross-referenced with ClinicalTrials.gov · ranked by match score (publications + PI activity + community signal)
No specialists are currently listed for NON RARE IN EUROPE: Juvenile idiopathic scoliosis.
Treatment Centers
8 centersSource: NORD Rare Disease Centers + NIH Undiagnosed Diseases Network (UDN) · centers verified active within last 12 months
Children's Hospital Colorado Rare Disease Program ↗
Children's Hospital Colorado
📍 Aurora, CO
👤 Boston Children's Hospital Rare Disease Program
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDBoston Children's Hospital Rare Disease Program ↗
Boston Children's Hospital
📍 Boston, MA
👤 Boston Children's Hospital Rare Disease Program
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
🏨 Children'sAnn & Robert H. Lurie Children's Hospital Genetics ↗
Lurie Children's Hospital
📍 Chicago, IL
👤 Boston Children's Hospital Rare Disease Program
🏥 NORDCincinnati Children's Hospital Medical Center ↗
Cincinnati Children's
📍 Cincinnati, OH
👤 Boston Children's Hospital Rare Disease Program
🏨 Children'sNationwide Children's Hospital Rare Disease Center ↗
Nationwide Children's Hospital
📍 Columbus, OH
👤 Boston Children's Hospital Rare Disease Program
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
Travel Grants
No travel grants are currently matched to NON RARE IN EUROPE: Juvenile idiopathic scoliosis.
Community
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Start the conversation →Latest news about NON RARE IN EUROPE: Juvenile idiopathic scoliosis
Source: PubMed + NIH RePORTER + openFDA + clinical-journal RSS · last 30 days · disease-tagged at ingest by AI extraction with human QC
No recent news articles for NON RARE IN EUROPE: Juvenile idiopathic scoliosis.
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Caregiver Resources
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Mental Health Support
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Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.How severe is my child's curve, and what is the Cobb angle measurement?,What is the risk that the curve will get worse as my child grows?,Does my child need bracing, and if so, how many hours per day should the brace be worn?,Should we get an MRI to rule out any underlying spinal cord problems?,What physical activities and sports are safe for my child?,How often should we schedule follow-up X-rays to monitor the curve?,At what point would surgery be recommended, and what surgical options are available for a child this age?
Common questions about NON RARE IN EUROPE: Juvenile idiopathic scoliosis
What is NON RARE IN EUROPE: Juvenile idiopathic scoliosis?
Juvenile idiopathic scoliosis is a sideways curvature of the spine that develops in children between the ages of 4 and 10 years old. The word 'idiopathic' means the cause is unknown — there is no clear underlying disease or condition that explains why the spine curves. This condition is sometimes simply called juvenile scoliosis. The spine may curve into a C-shape or S-shape, and the curve can worsen as the child grows, especially during growth spurts. Children with juvenile idiopathic scoliosis may notice that their shoulders or hips appear uneven, one shoulder blade sticks out more than the
How is NON RARE IN EUROPE: Juvenile idiopathic scoliosis inherited?
NON RARE IN EUROPE: Juvenile idiopathic scoliosis follows a multifactorial inheritance pattern. Genetic counseling can help families understand recurrence risk and testing options.
At what age does NON RARE IN EUROPE: Juvenile idiopathic scoliosis typically begin?
Typical onset of NON RARE IN EUROPE: Juvenile idiopathic scoliosis is juvenile. Age of onset can vary across affected individuals.
Are there clinical trials for NON RARE IN EUROPE: Juvenile idiopathic scoliosis?
Yes — 20 recruiting clinical trials are currently listed for NON RARE IN EUROPE: Juvenile idiopathic scoliosis on UniteRare. See the clinical trials section on this page for phase, sponsor, and site details sourced from ClinicalTrials.gov.
Frequently asked questions about NON RARE IN EUROPE: Juvenile idiopathic scoliosis
Auto-generated from canonical disease facts (Orphanet, OMIM, ClinicalTrials.gov, openFDA, NPPES). Not a substitute for clinical guidance.
What is NON RARE IN EUROPE: Juvenile idiopathic scoliosis?
NON RARE IN EUROPE: Juvenile idiopathic scoliosis is a rare disease catalogued in international rare-disease ontologies (Orphanet ORPHA:459696). It is typically inherited as multifactorial. Age of onset is generally juvenile. For verified primary sources, see the UniteRare NON RARE IN EUROPE: Juvenile idiopathic scoliosis page.
How is NON RARE IN EUROPE: Juvenile idiopathic scoliosis inherited?
NON RARE IN EUROPE: Juvenile idiopathic scoliosis follows multifactorial inheritance. Genetic counseling is recommended for affected families to understand recurrence risk in offspring and the likelihood of unaffected siblings being carriers. Variants in the underlying gene(s) may be identified via clinical genetic testing.
Are there FDA-approved treatments for NON RARE IN EUROPE: Juvenile idiopathic scoliosis?
Approved treatments for NON RARE IN EUROPE: Juvenile idiopathic scoliosis are tracked from openFDA and DailyMed primary sources. Many rare diseases have no specific FDA-approved therapy; for those, supportive care and management of complications form the basis of clinical care. Orphan-drug-designation status is noted where applicable.
Are there clinical trials recruiting for NON RARE IN EUROPE: Juvenile idiopathic scoliosis?
UniteRare currently lists 20 clinical trials relevant to NON RARE IN EUROPE: Juvenile idiopathic scoliosis sourced from ClinicalTrials.gov. Each trial entry includes recruitment status, eligibility criteria summary, principal-investigator information, and study locations. Patients should discuss eligibility with their healthcare provider before enrolling.
How do I find a specialist for NON RARE IN EUROPE: Juvenile idiopathic scoliosis?
Verified NON RARE IN EUROPE: Juvenile idiopathic scoliosis specialists are identified through ClinicalTrials.gov principal-investigator records, peer-reviewed publication authorship (via PubMed), and the NPPES NPI registry. NORD-designated Centers of Excellence and NIH-affiliated rare-disease clinics are also tracked. UniteRare's specialist directory is updated continuously as new evidence becomes available.
See full NON RARE IN EUROPE: Juvenile idiopathic scoliosis page for complete clinical details, sources, and verified-specialist listings.
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