What is NON RARE IN EUROPE: Immunoglobulin A deficiency?
Immunoglobulin A (IgA) deficiency, also called selective IgA deficiency or SIgAD, is the most common primary immune deficiency disorder in people of European descent. IgA is an antibody — a protein your immune system makes to fight off germs — that is especially important for protecting the lining of your nose, throat, lungs, and gut. When your body does not make enough IgA, these surfaces are less protected against bacteria and viruses. Many people with IgA deficiency have no symptoms at all and never know they have it. Others experience repeated infections, especially sinus infections, ear infections, and chest infections. Some people also develop allergies, asthma, or autoimmune conditions — where the immune system mistakenly attacks the body's own tissues. Digestive problems, such as chronic diarrhea or celiac disease, are also more common in people with IgA deficiency. There is no cure for IgA deficiency, but most people live normal or near-normal lives. Treatment focuses on managing infections quickly with antibiotics and treating any related conditions like allergies or autoimmune disease. Unlike some other immune deficiencies, IgA deficiency cannot be treated with standard immunoglobulin replacement therapy because most commercial preparations contain IgA, which can cause serious reactions in some IgA-deficient patients.
Also known as:
Key symptoms:
Frequent sinus infectionsRepeated ear infectionsRecurring chest infections or pneumoniaChronic diarrhea or stomach problemsAllergies or hay feverAsthmaCeliac disease or gluten sensitivityAutoimmune conditions such as rheumatoid arthritis or lupusInflammatory bowel diseaseReactions to blood transfusions or immunoglobulin productsNo symptoms at all (in many people)
- Inheritance
- Variable
- Can be inherited in different ways depending on the underlying gene
- Age of Onset
- Variable
- Can begin at different ages, from infancy through adulthood
Treatments
Source: openFDA + DailyMed · NDA / BLA labels with structured indications · refreshed weekly
No FDA-approved treatments are currently listed for NON RARE IN EUROPE: Immunoglobulin A deficiency.
View clinical trials →Clinical Trials
View all trials with filters →Source: ClinicalTrials.gov · synced daily · phases, status, and PI names normalized at ingest
No actively recruiting trials found for NON RARE IN EUROPE: Immunoglobulin A deficiency at this time.
New trials open frequently. Follow this disease to get notified.
Specialists
View all specialists →Source: NPI Registry + PubMed · trial PI roles cross-referenced with ClinicalTrials.gov · ranked by match score (publications + PI activity + community signal)
No specialists are currently listed for NON RARE IN EUROPE: Immunoglobulin A deficiency.
Treatment Centers
8 centersSource: NORD Rare Disease Centers + NIH Undiagnosed Diseases Network (UDN) · centers verified active within last 12 months
Children's Hospital Colorado Rare Disease Program ↗
Children's Hospital Colorado
📍 Aurora, CO
👤 Boston Children's Hospital Rare Disease Program
🔬 UDNHarvard/MGH UDN Clinical Site ↗
Massachusetts General Hospital
📍 Boston, MA
🏥 NORDBoston Children's Hospital Rare Disease Program ↗
Boston Children's Hospital
📍 Boston, MA
👤 Boston Children's Hospital Rare Disease Program
🏥 NORDUCLA Rare Disease Day Program ↗
UCLA Health
📍 Los Angeles, CA
🏨 Children'sAnn & Robert H. Lurie Children's Hospital Genetics ↗
Lurie Children's Hospital
📍 Chicago, IL
👤 Boston Children's Hospital Rare Disease Program
🏥 NORDCincinnati Children's Hospital Medical Center ↗
Cincinnati Children's
📍 Cincinnati, OH
👤 Boston Children's Hospital Rare Disease Program
🏨 Children'sNationwide Children's Hospital Rare Disease Center ↗
Nationwide Children's Hospital
📍 Columbus, OH
👤 Boston Children's Hospital Rare Disease Program
🔬 UDNNIH Clinical Center Undiagnosed Diseases Program ↗
National Institutes of Health
📍 Bethesda, MD
Travel Grants
No travel grants are currently matched to NON RARE IN EUROPE: Immunoglobulin A deficiency.
Community
No community posts yet. Be the first to share your experience with NON RARE IN EUROPE: Immunoglobulin A deficiency.
Start the conversation →Latest news about NON RARE IN EUROPE: Immunoglobulin A deficiency
Source: PubMed + NIH RePORTER + openFDA + clinical-journal RSS · last 30 days · disease-tagged at ingest by AI extraction with human QC
No recent news articles for NON RARE IN EUROPE: Immunoglobulin A deficiency.
Follow this condition to be notified when news becomes available.
Caregiver Resources
NORD Caregiver Resources
Support, advocacy, and financial assistance for caregivers of rare disease patients.
Mental Health Support
Rare disease caregiving can be isolating. Connect with counseling and peer support.
Family & Caregiver Grants
Financial assistance programs specifically for caregivers of rare disease patients.
Social Security Disability
Learn how rare disease patients may qualify for SSDI/SSI benefits.
Questions for your doctor
Bring these to your next appointment
- Q1.Do I need any special precautions before receiving blood transfusions or immunoglobulin treatments?,Should I be tested for related conditions like celiac disease or autoimmune disorders?,Do I need long-term antibiotics to prevent infections, or should I just treat infections as they come?,Are my vaccines up to date, and are there any vaccines I should or should not have?,Should my close family members be tested for IgA deficiency?,What symptoms should prompt me to seek urgent medical care?,Could my IgA deficiency progress to a more serious immune condition, and how would we monitor for that?
Common questions about NON RARE IN EUROPE: Immunoglobulin A deficiency
What is NON RARE IN EUROPE: Immunoglobulin A deficiency?
Immunoglobulin A (IgA) deficiency, also called selective IgA deficiency or SIgAD, is the most common primary immune deficiency disorder in people of European descent. IgA is an antibody — a protein your immune system makes to fight off germs — that is especially important for protecting the lining of your nose, throat, lungs, and gut. When your body does not make enough IgA, these surfaces are less protected against bacteria and viruses. Many people with IgA deficiency have no symptoms at all and never know they have it. Others experience repeated infections, especially sinus infections, ear
Frequently asked questions about NON RARE IN EUROPE: Immunoglobulin A deficiency
Auto-generated from canonical disease facts (Orphanet, OMIM, ClinicalTrials.gov, openFDA, NPPES). Not a substitute for clinical guidance.
What is NON RARE IN EUROPE: Immunoglobulin A deficiency?
NON RARE IN EUROPE: Immunoglobulin A deficiency is a rare disease catalogued in international rare-disease ontologies (Orphanet ORPHA:69127). It is typically inherited as variable. Age of onset is generally variable. For verified primary sources, see the UniteRare NON RARE IN EUROPE: Immunoglobulin A deficiency page.
How is NON RARE IN EUROPE: Immunoglobulin A deficiency inherited?
NON RARE IN EUROPE: Immunoglobulin A deficiency follows variable inheritance. Genetic counseling is recommended for affected families to understand recurrence risk in offspring and the likelihood of unaffected siblings being carriers. Variants in the underlying gene(s) may be identified via clinical genetic testing.
Are there FDA-approved treatments for NON RARE IN EUROPE: Immunoglobulin A deficiency?
Approved treatments for NON RARE IN EUROPE: Immunoglobulin A deficiency are tracked from openFDA and DailyMed primary sources. Many rare diseases have no specific FDA-approved therapy; for those, supportive care and management of complications form the basis of clinical care. Orphan-drug-designation status is noted where applicable.
Are there clinical trials for NON RARE IN EUROPE: Immunoglobulin A deficiency?
Active clinical trials for NON RARE IN EUROPE: Immunoglobulin A deficiency are tracked daily from ClinicalTrials.gov. Trial availability changes frequently; check the UniteRare trial listings for the current count and recruitment status. Sponsors of rare-disease research often welcome inquiries even when a trial is not actively recruiting at a given moment.
How do I find a specialist for NON RARE IN EUROPE: Immunoglobulin A deficiency?
Verified NON RARE IN EUROPE: Immunoglobulin A deficiency specialists are identified through ClinicalTrials.gov principal-investigator records, peer-reviewed publication authorship (via PubMed), and the NPPES NPI registry. NORD-designated Centers of Excellence and NIH-affiliated rare-disease clinics are also tracked. UniteRare's specialist directory is updated continuously as new evidence becomes available.
See full NON RARE IN EUROPE: Immunoglobulin A deficiency page for complete clinical details, sources, and verified-specialist listings.
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